基本説明
Included are descriptions of the cutting-edge nuclear-magnetic-resonance and electron-paramagnetic-resonance spectroscopic techniques, the dynamics of ultra-fast reactions, and the central problem of molecular oxygen activation in biological processes.
Description
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Chemische Forschung zur Aufklärung biologischer Prozesse: Dieser Band ist definitiv ein Muß für alle, die sich aus erster Hand einen Überblick über den gegenwärtigen Forschungsstand, den historischen Weg und die Zukunftsaussichten verschaffen möchten. Von der Entwicklung der Röntgenstrukturanalyse über spektakuläre Anwendungen der NMR- und EPR-Spektroskopie bis zur Dynamik ultraschneller Reaktionen, von chiralen Reagenzien über photochemische Naturstoffsynthesen bis zur kombinatorischen Chemie, von der molekularen Erkennung bis zur Medizinethik: Das Themenspektrum ist so breit gefächert, daß kaum eine Frage unbeantwortet bleibt. Die Autoren, darunter zwei Nobelpreisträger, zählen zu den besten Naturwissenschaftlern der internationalen Community.
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In this volume, internationally renowned chemists recount their roles in the progress of chemistry research toward elucidation of biological processes. Beginning with a historical perspective on the development of X-ray crystallography, the reader is regaled with first-hand accounts ofresearch milestones. Included are descriptions of the cutting-edge nuclear-magnetic-resonance and electron-paramagnetic-resonance spectroscopic techniques, the dynamics of ultra-fast reactions, and the central problem of molecular oxygen activation in biological processes. The roles of chiral auxiliaries in organic synthesis and of photochemistry in natural product synthesis are told, and innovations in combinatorial synthesis approaches are described. Contemporary issues in molecular recognition and modulation of molecular function are addressed, concluding with a missive regarding how the frontiers of medical ethics may be breached by molecular manipulations.
(Table of content)
From the content:
- The Gold-Mine Parabel (by Albert Eschenmoser)
- Looking Backwards: Half a Century of Chemical Crystallography (by Jack D. Dunitz)
- NMR Spectroscopy as a Tool for the Determination of Structure and Dynamics of Molecules (by Christian Griesinger)
- New Methods in Electron Paramagnetic Resonance Spectroscopy for Structure Determination in Biological Systems (by Thomas Prisner)
- Reactivity Concepts for Oxidation Catalysis: Spin and Stoichiometry Problems in the Activation of Dioxygen (by Helmut Schwarz)
- Femtosecond Activation of Reactions: The Concepts on Behavior and Reduced-Space Dynamics (by Ahmed Zewail)
- Photochemistry Meets Natural-product Synthesis (by Gerhard Quinkert)
- TADDOL - Our Dream of Universal Chiral Auxiliaries (by Dieter Seebach)
- Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries (by Jean-Marie Lehn)
- The Importance of ß-Alanine for Recognition of the Minor Groove of DNA (by Peter B. Dervan)
- Generating New Molecular Funct tion: A Lesson from Nature (by Peter G. Schultz)
- Ethical Limits to 'Molecular Medicine' (by Ernst-Ludwig Winnacker)
- Synthesis of the Co-Enzyme B12: a Vehicle for Teaching Organic Synthesis (by Albert Eschenmoser)
