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Full Description
Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of CMV-reactive T cells in protection, pathogenesis, diagnosis and therapy of HCMV infection is discussed. The contributions to this book are written by leading scientists and clinicians in the field of CMV who participated in the fourth international meeting on CMV-related immunopathology, held in Berlin, September 2002. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working in the field of herpesvirus biology and the development of antiviral drugs.
Contents
Part I CMV Pathogenesis: Virus- and Immune-Related Effects; The Endothelium as a Mediator of CMV-Associated Immunopathology, Waldman, W.J., Magro, C.M., Knight, D.A.; Effect of CMV Infection on Chronic Rejection of Kidney Transplants, Lautenschlager, I. et al.; CMV and Atherosclerosis, Stassen. F.R.M., Vliegen, I., Bruggeman, C.A.; Human Cytomegalovirus in Immune Privileged Sites - HCMV Retinitis and the Role of NF-kB, Scholz, M., Vogel, J.-U., Doerr, H.W., Cinatl, J.; Transmission of Cytomegalovirus to Preterm Infants by Breast-Feeding: Hamprecht, K., Maschmann, J., Vochem, M., Speer, C.P., Jahn, G.; Human Cytomegalovirus Escapes Cell-Mediated Immune Responses, Odeberg, J., Naucl r, C.S.; Counteraction of Interferon-Induced Antiviral Responses by Cytomegalovirus, Zimmermann, A., Trilling, M., Wilborn, M., Hengel, H.; Mechanisms of Immunodominance in Human Cytomegalovirus Infection, Frankenberg, N., Pepperl-Klindworth, S., Plachter, B.; HCMV Latency and Lytic Gene Regulations - A Question of Chromatin Structure?, Murphy, J.C. et al.; Taking Away the Replication License HCMV and Its Impact on Cellular DNA Synthesis, Wiebusch, L., Hagemeier, C.; Interactions and Functions of Human Cytomegalovirus Tegument Proteins, Winkler, M. Part II Novel Strategies in HCMV Diagnostics and Therapy: Measuring T-Cell Reactivity to Cytomegalovirus - State of the Art: Hoffmeister, B. et al.; Measurement of CMV DNA Levels and CMV-Specific CD4+ Lymphocyte Counts in Patient Specimens - Requirements for Test Quality and Practicability in a Routine Diagnostic Service, Preiser, W., Buxbaum, S., Fleckenstein, C., Doerr, H.W.; Manipulation of CMV-Specific Immune Responses following Stem Cell Transplantation, Einsele, H.; Fast Genotypic Identification and Estimation of Ganciclovir-Resistant Cytomegalovirus from Clinical Specimens, Michel, D. et al.; Non-Nucleoside Inhibitors of HCMV Replication, Neyts, J., De Clercq, E.; New Concepts for Inhibition of HCMV Reactivation and Replication, Pr sch, S., Wuttke, R. Kr ger, D.H., Volk, H.-D.; CMV Vaccines to Prevent Congenital Infection - An Overview of Preclinical and Clinical Results, Meric, C.; Cadoz, M.
