Full Description
Prevention and treatment of nausea and emesis are important issues in a patient's wellbeing in the clinical setting as well as for the outpatient. Various and still partly unresolved pathomechanisms play a role in nausea and emesis in humans. It is therefore important to compare results from preclinical research in animal models with results from clinical studies. This book combines an overview of the preclinical research on antiemetic drugs and state-of-the art reviews on the prevention and treatment of nausea and emesis. Established treatment regimens are compared with new interesting compounds in clinical trials. An up-to-date overview of the selection of antiemetic drugs, of their dosage and route of administration is given for clinical conditions such as emetogenic anti-cancer chemotherapy, radiation therapy, surgery, and hyperemesis gravidarum. The treatment of nausea and emesis in opioid therapy and in motion sickness is equally outlined. Whereas this book should serve the clinician in making the right choice for every patient's need, it also pays significant attention to the interests of scientists in the fields of oncology, nutrition, gastroenterology, obstetrics and gynecology as well as anaesthesia.
Contents
The Emetic Reflex Arc, Donnerer, J.; Receptive Mechanisms of Noxious Stimulation of Emesis, Lang, I.M.; 5-HT3 Receptor Antagonists in Antiemetic Therapy, Donnerer, J., Beubler, E.; The Site of Antiemetic Action of NK1 Receptor Antagonists, Fukuda, H., Koga, T., Furukawa, N., et al; Potential of Substance P Antagonists as Antiemetics, Diemunsch, P., Grelot, L.; Neuronal Mechanisms and Treatment of Motion Sickness, Schmal, F., Stoll, W.; Management of Opioid-Induced Nausea and Emesis, Aparasu, R.R., Aparasu, A.; Prevention and Treatment of Postoperative Nausea and Vomiting, Kovac, A.L.; Metoclopramide for the Control of Postoperative Nausea and Vomiting, Henzi, I., Tramer, M.R.; Prevention of Delayed Nausea and Emesis Induced by Chemotherapy, Roila, F.; Prophylaxis of Radiation-Induced Emesis, Maranzano, E.; Pharmacotherapy for Nausea and Vomiting in Early Pregnancy, Kusu, N.K.; Hyperemesis gravidarum in the Clinical Setting, Eliakim, R., Abulafia, O., Sherer, D.M.
