Full Description
Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.
Contents
Epidemiology of Non-Steroidal Anti-Inflammatory Drugs and Cancer, Baron, J.A.; Pharmacology of COX-2 Inhibitors, Isakson, P.C.; Regulation of COX-2 Expression in Human Cancers, Dixon, D.A.; Cyclooxygenase-2 and Skin Carcinogenesis, Furstenberger, G., Marks, F., M ller-Decker, K.; The Role of COX-2 in Breast and Cervical Cancer, Dannenberg, A.J., Howe, L.R.; Cyclooxygenase-2, A Target for the Prevention and Treatment of Cancers of the Upper Digestive Tract, Altorki, N.K., Subbaramaiah, K., Dannenberg, A.J.; Cyclooxygenase-2 and Colorectal Cancer, DuBois, R.N.; Cyclooxygenase-2 in Lung Cancer, Dubinett, S.M., Sharma, S., Huang, M., Dohadwala, M., Pold, M., Mao, J.T.; COX-2 Inhibitors and Other NSAIDs in Bladder and Prostate Cancer, Sabichi, A.L., Lippman, S.M.; Therapeutic Potential of Selective Cyclooxygenase-2 Inhibitors in the Management of Tumor Angiogenesis, Gately, S., Kerbel, R.; Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation, Saha, D., Choy, H.; Non-Steroidal Anti-Inflammatory and Cyclooxygenase-2-Selective Inhibitors in Clinical Cancer Prevention Trials, Hawk, E.T., Viner, J.L., Umar, A.; Chemotherapy with Cyclooxygenase-2 Inhibitors in the Treatment of Malignant Disease, Pre-Clinical Rationale and Preliminary Results of Clinical Trials, Blanke, C.D., Masferrer, J.L.; Role of COX-Independent Targets of NSAIDs and Related Compounds in Cancer Prevention and Treatment, Soh, J.-W., Weinstein, I.B.
