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Full Description
Volume 105 of Developments in Biologicals reports scientific presentations on the latest progress in polio eradication and vaccination given at an international symposium held in June 2000. The following topics are covered: - the highly impressive progress towards global eradication and the role of the WHO Polio Eradication Program - the efficiency and reliability of virological surveillance and the scientific basis for certification of eradication, including perspectives from countries in the developing world as well as from the developed - updates on the molecular biology and genetics of poliovirus and poliovaccines, including the molecular basis for attenuation and reversion to virulence and the interesting area of receptor specificity for polio and other enteroviruses - the advantages and disadvantages of current poliovaccines and immunization strategies, reviewed by participants from industry and public health organizations - the role of inactivated poliovaccines in the end game and the vexed question of when and how vaccination against polio can be safely suspended as well as the risks of re-introduction of polio post-eradication and post-vaccination - gaps in scientific knowledge in the fields of virology, immunology and epidemiology relevant to the end game of polio eradication and priorities for future scientific research This volume will remain a key reference on polio eradication and vaccination for many years to come, not only for academic researchers but also for members of public health organizations, vaccine manufacturers and managers of immunization programs.
Contents
Session I Status of Polio Eradication - Chairperson W. Orenstein: Progress Towards Global Polio Eradication, H.F. Hull; Progress Towards Polio Eradication - An African Perspective, B.D. Schoub, et al.; The Efficiency and Reliability of Polio Surveillance, T. Hovi; A Scenario for Polio Eradication, I. Arita. Session II The Biology and Molecular Biology of Polioviruses - Chairperson, J. Almond: Some Problems of Molecular Biology of Poliovirus Infection Relevant to Pathogenesis, Viral Spread and Evolution: V.I. Agol, et al.; The Molecular Basis of Poliovirus Neurovirulence, S. Ohka, A. Nomoto. Session III Current Poliovirus Vaccines - Chairperson, D. Wood: Strengths and Weaknesses of Current Polio Vaccines - A View from Industry, F.E. Andre. Session IV When and How Can We Stop Vaccination? - Chairperson, J. Furesz: The Scientific Basis for Stopping Polio Immunisation - Issues and Challenges, D.J. Wood. Session V Risks of Reintroduction of Polio Post-Eradication - Chairperson, T. Hovi: Characteristics of Poliovirus Strains from Long-Term Excretors with Primary Immunodeficiencies, P.D. Minor. Session VI Post Eradication Issues - Chairperson, B. Schoub: Will the Polio Niche Remain Vacant?, E. Rieder, et al.; The Eradication of Foot-and-Mouth Disease - A Parallel Problem, F. Brown; Stopping a Polio Outbreak in the Post-Eradication Era, P.E.M. Fine, R.W. Sutter, W.A. Orenstein; Roundtable Discussion - What Are the Gaps in Our Scientific Knowledge Relevant to Stopping Polio Immunisation?, D.J. Wood. Session VII Possible Strategies for Stopping Immunisation - Chairperson Sir J. Smith: Possible Global Strategies for Stopping Polio Vaccination and How They Could Be Harmonized, S.L. Cochi, R.W. Sutter, R.B. Aylward; Roundtable Discussion - Possible Strategies for Stopping Immunisation, D.J. Wood. Session VIII What Vaccines Could Be Used Post-Eradication if They Were Needed? - Chairperson, J. Petricciani: Progress with Inactivated Poliovirus Vaccines Derived from the Sabin Strains, Y. Doi, et al.; Inactivated Vaccines Based on Alternatives to Wild-Type Seed Virus, K. Chumakov, et al.; Live-Attenuated Strains of Improved Genetic Stability, A.J. Macadam, et al.; Vaccines Based on Recombinant Antigen Strategies, P.D. Minor. (Part contents)
