Full Description
Bridging the wide information gap for the clinician and researcher alike, this text contains numerous clinical photographs, statistical data, and concise descriptions of the initial mucocutaneous symptoms, to help the clinician to understand and identify the disease. Other manifestations of BD in such systems as the cardiac, vascular, pulmonary, gastrointestinal, to name a few, are also described. In addition, the book surveys the drugs and other therapeutic modalities known to have beneficial effects. Lastly, the books synopsis of the pathogenic and immunologic features of the disease will be useful to scientists interested in the research aspects of BD.
Contents
I Special Contribution.- Advances in the Immunopathogenesis of Behcet's Disease.- II Clinical Understanding of Behcet's Disease.- 1 Introduction.- 1.1 Definition.- 1.2 Synonyms.- 1.3 Other Common Terms.- 1.4 History.- 1.5 Epidemiology.- 2 Etiopathogenesis.- 2.1 Viral Infection.- 2.2 Bacterial Infection.- 2.3 Heat Shock Protein.- 2.4 Environmental Pollution.- 2.5 Autoimmune Theory.- 2.6 Immunogenetics.- 2.6.1 Familial Occurrence.- 2.6.2 Immunogenetic Aspect.- 3 Clinical Manifestations.- 3.1 Major and Minor Symptoms.- 3.1.1 Occurrence.- 3.1.2 Initial Manifestations.- 3.2 Oral Ulcers.- 3.2.1 Clinical Manifestations.- 3.2.2 Clinical Course of Oral Ulcers.- 3.2.3 Experimentally Induced Oral Ulcers.- 3.2.4 Sequelae from Recurrent Episodes of Oral Ulcers.- 3.2.5 Pediatric Oral Ulcers.- 3.2.6 Prognosis of Recurrent Oral Ulcers.- 3.3 Genital Ulcers.- 3.3.1 Clinical Features.- 3.3.2 Clinical Course of Genital Ulcers.- 3.3.3 Other Urogenital Features.- 3.4 Cutaneous Manifestations.- 3.4.1 Clinical Features.- 3.5 Ocular Manifestations.- 3.5.1 Clinical Features.- 3.5.2 Clinical Course.- 3.5.3 Pediatric Ocular Manifestations.- 3.5.4 Prognosis.- 3.6 Joint Manifestations.- 3.6.1 Clinical Features.- 3.6.2 Clinical Course.- 3.6.3 Joint Involvement in Pediatric Patients.- 3.6.4 Operative Findings.- 3.7 Gastrointestinal Involvement.- 3.8 Vascular Manifestations.- 3.9 Neurologic and Psychiatric Manifestations.- 3.9.1 Clinical Features.- 3.9.2 Clinical Progress.- 3.10 Other Organ Manifestations.- 3.11 Pregnancy-Associated Manifestations.- 4 Diagnosis.- 4.1 Diagnostic Criteria.- 4.2 Pathergy (Skin Hyperreactivity).- 4.3 Laboratory Findings.- 4.4 Differential Diagnosis.- 5 Immunologic Aspects.- 5.1 Cell-Mediated Immunity.- 5.1.1 DNCB Responsiveness.- 5.1.2 T and B Cells.- 5.1.3 Antibody-Dependent Cellular Cytotoxicity (ADCC) and Natural Killer (NK) Cells.- 5.1.4 Cytokines.- 5.2 Humoral Immunity.- 5.2.1 Serum Immunoglobulins.- 5.2.2 Circulating Immune Complexes.- 5.2.3 Autoantibodies.- 6 Histopathology.- 6.1 Characteristics.- 6.2 Light Microscopic Findings.- 6.3 Electron Microscopic Findings.- 7 Interdepartmental Cooperation Approach System.- 8 Therapy.- 9 Prognosis.- 10 Prevention.- 11 Animal Models.- 11.1 Environmental Pollution.- 11.2 HLA-B51.- 11.3 Heat Shock Protein.- 11.4 Herpes Simplex Virus Infection.- Appendix Special issue on Behcet's Disease of Yonsei Medical Journal (Vol 38, No. 6, December 1997).- Appendix 1 Life Story of Dr. Hulusi Behcet.- Appendix 2 Molecular Genetics (HLA) of Behcet's Disease.- Appendix 3 Behcet's Disease Etiopathology: Immunological Aspects*.- Appendix 4 Etiopathology of Behcet's Disease: Herpes Simplex Virus Infection and Animal Model.- Appendix 5 Diagnostic Criteria of Behcet's Diesease: Problems and Suggestions.- Appendix 6 Recurrent Aphthous Stomatitis in the Diagnosis of Behcet's Disease*.- Appendix 7 Dermatologic Manifestation of Behcet's Disease.- Appendix 8 Ophthalmologic Manifestations of Behcet's Disease.- Appendix 9 Behcet's Disease - A Rheumatologic Perspective.- Appendix 10 Treatment of Behcet's Disease.- Appendix 11 Adamantiades-Behcet's Disease: Epidemiology in Germany and in Europe*.- Appendix 12 Clinical Manifestations of Behcet's Disease: An Analysis of 2147 Patients*.- Appendix 13 Epidemiological and Clinical Features of Behcet's Disease in Korea.- Appendix 14 The Influence of Pregnancy on Behcet's Disease.- Appendix 15 Immunological Aspects of Hyperreactivity to Streptococcal Antigens in Behcet's Disease*.- Appendix 16 Surgical Treatment of Intestinal Behcet's Disease.
