Full Description
This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.
Contents
Basic Aspects: The Epidermal Barrier and Strategies for Surmounting it. Stem Cells, Differentiation and Renewal Kinetics of Keratinocytes. Relevant Animal Models for Skin Gene Therapy. Non-viral gene transfer into the skin. Safety and Pharmacokinetics of Naked Plasmid DNA. Uptake of DNA by Keratinocytes. Treatment of Skin Diseases: Gene Therapy of Inherited Skin Diseases. Gene Transfer Strategies in Tissue Repair. Systemic Effects of Skin Gene Therapy: The Use of Skin-directed Gene Therapy in the Treatment of Systemic Diseases. Keratinocyte Gene Therapy using Cytokine Genes. Genetic Vaccination using the Skin: Principles of Genetic Immunization. Systematic Modulation of Immune Responses by CpG DNA. Genetic and Dendritic Cell Vaccination as a Novel Therapy for Melanoma. Molecular Strategies Interfering with Oncogene Expression and Tumor Progression of Melanoma and Improving Anti-Tumor Immunity. Prophylactic and Therapeutic DNA Vaccines against Infectious Diseases.
