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Full Description
Classified by their mode of action, all important classes of analgesics are presented here, including recent developments that have not yet been introduced to the market. Altogether, more than 300 compounds are described. A carefully designed layout presents the most relevant information at a glance, including compound structure, physical properties, synthesis schemes and clinical uses. Trade names for different countries are also given, allowing quick reference to compounds currently on the market. In addition to proven pain relievers, novel approaches to pain treatment are discussed and drug candidates for future therapies are presented. With its broad scope and extensive compound listings, this is a premier reference source for pain treatment by pharmacological means. A valuable resource for clinicians, drug developers and pain researchers.
Contents
Preface.A View from Grunenthal.PART I: INTRODUCTION. What is Pain? (H. Buschmann). PART II: PAIN THERAPY TODAY. Cyclooxygenase Inhibition: From NSAIDS to Selective COX 2 Inhibitors (T. Christoph & H. Buschmann). Opioids. NA and 5 HT Reuptake Inhibitors and alpha2 Agonists (T. Tzschentke). PART III: NEW APPROACHES IN PAIN THERAPY. Gabapentin and Gabapentinoids (C. Maul, et al.). Voltage gated Ion Channels. Glutamate Receptors. Acetylcholine Receptors. Further Opioid Receptors. Adenosine (C. Maul, et al.). P2 Receptors (H. Hennies, et al.). Natural and Synthetic Cannabinoids (C. Maul & B. Sundermann). Vanilloids and the VR1 Receptor (R. Frank). Substance P/NK1 Receptors (G. Bahrenberg & C. Maul). CGRP1 Receptor Antagonists (C. Gillen). Nitric Oxide (C. Maul, et al.). PART IV: OUTLOOK. Outlook The Future of Pain Management (U. Jahnel & C. Gillen). Glossary.