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Full Description
Providing the first comprehensive book on the current state of hyperpolarized Xenon-129 NMR and MRI, this book is guaranteed to appeal to a wide range of scientists interested in this growing field. It is intended to create synergy between the various communities working with this noble gas.
Covering all topics from the production of the hyperpolarized gas to its applications, the editors have invited a leading team of experts to combine the physical chemistry within the various topics and across disciplines. The scope will range from the fundamental aspects of optical pumping to practical aspects of hyperpolarizers and hp-xenon handling. The applications section will focus on hyperpolarized xenon-129 detected in the dissolved phase or micro porous media where the chemical shift of xenon-129 can be used as a diagnostic probe.
Appealing to researchers in the biomedical field and materials sciences, this reference book will provide background reading and future looking material in one place.
Contents
Xenon as a Probe Atom: Introduction, Characteristics, Investigation of Microporous Solids; The Xenon Chemical Shift and Chemical Shift Anisotropy; Spin Exchange Optical Pumping (SEOP) - Concepts and Practical Considerations; Optimization of Pump Cells: Simulation and Experiments; Large Volume and Continuous Flow Hyperpolarization; Spin-Exchange Optical Pumping at High Xenon Densities and Laser Fluxes: Principles and Practice; T1 Relaxation of 129Xe and How to Keep It Long; Hyperpolarized 129Xe NMR in Materials Sciences: Pore Structure, Interconnectivity and Functionality; Porous Materials Explored by Hyperpolarized Xenon NMR; Xenon Porometry; HP Xe-129 NMR Characterization of Single-File Diffusion in Nanotubes; Studies of Metal-Organic Frameworks: Xenon for Probing Framework Porosity, Breathing and Gating Behavior; Hyperpolarized Xenon Biosensors and HyperCEST; Biosensing and Study of Biological Cells Using Hyperpolarized 129Xe; Cryptophane-Based 129Xe NMR Biosensors; Caged Xenon in Phospholipid Membrane Environments; Continuous Flow and Dissolved Phase 129Xe NMR/MRI for Quantification in Preclinical Study as well as Materials Science; Hyperpolarized Xenon-129 Gas Uptake in the Human Lung and XTC MRI; Xenon Septal Uptake; 129Xe Chemical Shift and Spin-lattice Relaxation Dependences on Blood Oxygenation; Transverse Relaxation of 129Xe in the Lung; Magnetic Resonance Imaging of the Brain using Hyperpolarized 129Xe; Beyond Spin I = ½ - Hyperpolarized 131Xe and 83Kr Magnetic Resonance; Beyond Spin Exchange Optical Pumping: Hyperpolarization of 129Xe via Sublimation Dynamic Nuclear Polarization; Rethinking the Detection Scheme: Hyperpolarized Xenon NMR and MRI Signal Amplification by Gas Extraction and Remote Detection; Subject Index
