Full Description
Two types of cholinesterases (ChEs) are found in the mammalian brainacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). They are products of two different genes and exhibit different localizations and kinetic properties. Until recently, the function of BuChE and its role in the regulation of acetylcholine levels in the central nervous system have been largely unknown. There is now evidence that BuChE plays a vital role in the brain cholinergic system, and that it may have a key role in the development of Alzheimer's disease. Butyrylcholinesterase: Its Function and Inhibitors is for neurologists, psychiatrists, geriatricians and neuroscientists who want a full profile of BuChE.
Contents
ButyrylcholinesteraseButyrylcholinesterase Function in the Acetylcholinesterase Knockout Mouse, O. Lockridge, E.G. Duysen, and B. LiButyrylcholinesterase in the Normal and Alzheimer Brain, M.-M. MesulamComparison of the Structures of Butyrylcholinesterase and Acetylcholinesterase, F. Nachon, P. Masson, Y. Nicolet, O. Lockridge, and J.C. Fontecilla-CampsGenetic Variation in Butyrylcholinesterase and the Physiological Consequences for Acetylcholinesterase Function, D. Glick, L. Ben-Moyal, and H. SoreqButyrylcholinesterase: Its Selective Inhibition and Relevance to Alzheimer's Disease Therapy, N.H. Greig, K. Sambamurti, Q.-S. Yu, T.A. Perry, H.W. Holloway, F. Haberman, A. Brossi, D.K. Ingram, and D.K. LahiriButyrylcholinesterase: Studies with Brain Imaging, A. Nordberg, E. Stefanova, T. Darreh-Shori, and A. WallButyrylcholinesterase and Cocaine, S. Brimijoin and O. LockridgeThe Preclinical Pharmacology of Butyrylcholinesterase, A. EnzThe Role of Butyrylcholinesterase in Alzheimer's Disease, C.G. Ballard and E.K. PerryButyrylcholinesterase K Variant in Alzheimer's Disease, D. Lehman and A.D. SmithButyrylcholinesterase and Dementia with Lewy Bodies: Involvement in Symptom Progression and Treatment Response, I.G. McKeith, K.K. O'Brien, C.M. Morris, and E.K. PerryButyrylcholinesterase: Its Use for Prophylaxis of Organophosphate Exposure, B.P. Doctor
