基本説明
Reviews the challenges posed for drug development; Identifies rational molecular targets for cancer therapy; Clarifies why current therapies so often fail to cure solid tumors.
Full Description
World reknown basic scientists and clinical researchers update the wealth of new molecular knowledge that sees cancer as a 'disease process' involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Comprehensive and path-breaking, "Principles of Molecular Oncology, Second Edition" offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's strategies for its diagnosis and treatment.
Contents
Part I. Molecular Markers Selecting the Right Targets for Cancer Therapy Miguel H. Bronchud Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful Daniel F. Hayes Genetic Markers in Sporadic Tumors Antonella Aiello, Elena Tamborini, Milo Frattini, Federica Perrone, Maria Oggionni, Silvana Pilotti, and Marco A. Pierotti Genetic Markers in Breast Tumors with Hereditary Predisposition Tatyana A. Grushko and Olufunmilayo I. Olopade Cellular and Tissue Markers in Solid Tumors Barbro Linderholm, Thomas Lindahl, John Ohd, and Jonas Bergh Molecular and Pathologic Characterization of Human Tumors Chris Jones, Ming-Qing Du, and Sunil R. Lakhani Circulating Tumor Markers Alan Horwich and Gill Ross Proteomics-Based Approaches: New Opportunities in Cancer Research Rachel A. Craven, Peter J. Selby, and Rosamonde E. Banks Part II. Diseased Regulatory Pathways Growth Factor Signaling Pathways in Cancer Daniel Kalderon Estrogen Action and Breast Cancer Jennifer E. Fox, Hong Liu, and V. Craig Jordan Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics Miguel H. Bronchud, Leonardo Brizuela, Jeno Gyuris, and Muzammil M. Mansuri Angiogenesis Switch Pathways Jaume Piulats and Francesc Mitjans Invasion and Metastasis Maria Rosa Bani and Raffaella Giavazzi Molecular Pathways of Drug Resistance Linda E. Broker, Jose A. Rodriguez, and Giuseppe Giaccone Genomic Instability, DNA Repair Pathways, and Cancer Gabriel Capella and Miguel Angel Peinado Part III. Future Directions Immunotherapy for Human Cancer: Evidence and Obstacles Angelo A. Cardoso, W. Nicholas Haining, Marina Leite, and Sara Maia Treatment with Monoclonal Antibodies Gisela Schwab, Lorin Roskos, and C. Geoffrey Davis Emerging Molecular Therapies: Drugs Interfering with Signal Transduction Pathways Richard Baird and Paul Workman Treatment of Carcinogenesis M. Suzanne Stratton, Steven P. Stratton, Sara O. Dionne, Patricia Thompson, Ian N. Jongewaard, Iman Hakim, Tarrah Dilley, Linda Garland, James Ranger-Moore, David S. Alberts, and Frederick M. Ahmann Suicide Gene Therapy Ion Niculescu-Duvaz and Caroline J. Springer Glossary Index
