基本説明
Features many new knockouts, with emerging phenotyic patterns and provides a more precise understanding of the impact of each cytokine knockout.
Full Description
Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
Contents
I. Cytokine Knockouts in Models of Human Disease.- 1. Cytokine Knockouts in Inflammation.- 2. The Use of Cytokine Knockouts to Study Host Defense Against Infection.- 3. The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease.- 4. The Use of Cytokine Knockout Mice in Cancer Research.- 5. The Use of Cytokine Knockout Mice in Neuroimmunology.- II. Cytokine Knockout Mice.- 6. The Role of IL-1 in the Immune System.- 7. IL-1 Receptor Antagonist-Deficient Mice.- 8. A Unique Role for IL-2 in Self-Tolerance.- 9. Molecular Basis for Binding Multiple Cytokines by ?c: Implications for X-SCID and Impaired ?c-Dependent Cytokine Receptor Function.- 10. G-CSF, GM-CSF, and IL-3 Knockout Mice.- 11. IL-4 Knockout Mice.- 12. Role of IL-5 in Immune and Pathological Responses in the Mouse.- 13. IL-6 Knockout Mice.- 14. IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation.- 15. IL-12-Deficient Mice.- 16. IL-13 and Double IL-4/IL-13 Knockout Mice.- 17. IL-15: Insights from Characterizing IL-15-Deficient Mice.- 18. IL-18 and IL-18 Receptor Knockout Mice.- 19. Mice Knockouts for Chemokines and Chemokine Receptors.- 20. IFN-? and IFN-? Receptor Knockout Mice.- 21. Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice.- 22. Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice.- 23. RANKL, RANK, and OPG.- 24. Targeting the TGF-? Pathway In Vivo: Defining Complex Roles for TGF-? Signaling in Immune Function, Wound Healing, and Carcinogenesis.- 25. Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models.
