基本説明
Features chapters on GABA receptors, glutamate receptors as well as glutamate transporters and other neurotransmitters.
Full Description
A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.
Contents
I. Molecular Pharmacology of Glutamate Receptors.- 1 Computational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate Receptors.- 2 Delineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective Ligands.- 3 Molecular Pharmacology of the Metabotropic Glutamate Receptors.- II. Molecular Pharmacology of GABA Receptors.- 4 Functional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo Activity.- 5 In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice.- 6 Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling.- 7 The GABAB Receptor: From Cloning to Knockout Mice.- III. Molecular Pharmacology of Transmitter Transporters.- 8 Structure and Molecular Characterization of the Substrate-Binding Sites of the Dual-Function Glutamate Transporters.- 9 Allosteric Modulation of Glutamate Transporters.- 10 Characterization of the Substrate-Binding Site in GABA Transporters.- 11 Insights From Endogenous and Engineered Zn2+ Binding Sites in Monoamine Transporters.- 12 A Structural Context for Studying Neurotransmitter Transporter Function.- 13 Functional Mechanisms of G Protein-Coupled Receptors in a Structural Context.
