Full Description
A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.
Contents
Part I. Introduction
Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumors
Marc Ladanyi and William L. Gerald
Part II. Technical Aspects
cDNA Microarrays
Paul S. Meltzer
Oligonucleotide Microarrays
Marina Chicurel and Dennise Dalma-Weiszhausz
Serial Analysis of Gene Expression (SAGE) in Cancer Research
C. Marcelo Aldaz
Tissue Arrays
Cyrus V. Hedvat
Microarray Data Analysis: Cancer Genomics and Molecular Pattern Recognition
Pablo Tamayo and Sridhar Ramaswamy
The Role of Tumor Banking and Related Informatics
Stephen J. Qualman, Jay Bowen, Sandra Brewer-Swartz, and Mary France
Part III. Applications
Characterization of Gene Expression Patterns for Classification of Breast Carcinomas
Irene L. Andrulis, Nalan Gokgoz, and Shelley B. Bull
Microarray Analysis of Colorectal Cancer
Daniel A. Notterman, Carrie J. Shawber, and Wei Liu
Gene Expression Analysis of Prostate Carcinoma
William L. Gerald
Classification of Human Lung Carcinomas by mRNA Expression Profiling
Arindam Bhattacharjee and Matthew Meyerson
Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarrays
Marta Sánchez-Carbayo and Carlos Cordon-Cardo
Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications
Masayuki Takahashi and Bin Tean Teh
Expression Profiling of Pancreatic Ductal Adenocarcinoma
Christine A. Iacobuzio-Donahue and Ralph H. Hruban
Gene Expression in Ovarian Carcinoma
Garret M. Hampton
Classification of Pediatric Tumors Using DNA Microarrays
Javed Khan and Marc Ladanyi
Transcriptomes of Soft Tissue Tumors: Pathologic and Clinical Implications
Sabine C. Linn, Rob B. West, and Matt van de Rijn
Gene Expression Profiling inLymphoid Malignancies
Wing C. Chan and Louis M. Staudt
Gene Expression Profiling of Brain Tumors
Meena K. Tanwar and Eric C. Holland
Expression Profiling of Bone Tumors
Deborah Schofield, Daniel Wai, and Timothy J. Triche
Index