Full Description
Trauma and exposure to toxic and infectious agents invariably lead to organ damage followed by significant morbidity and mortality. Although these conditions have typically been associated with the battlefield, today they are more prevalent in urban areas. The events of September 11,2001 have brought this problem to the forefront of national and international concern. The demand for solutions is justifiably high, and the research community needs to adjust its efforts appropriately. Combat Medicine is meant to be a concise manual for the young clinical or basic investigator who is studying organ injury following trauma or toxic or infectious assaults either in an urban or battlefield setting, with an emphasis on current research issues in emergency and military medicine. The aim of Combat Medicine is to inspire surgical and medical residents and fellows, as well as biology and biochemistry students and fellows, to pursue research careers in the fields of military, trauma, and emergency medicine. Combat Medicine is not intended to be an exhaustive review; rather it is an introduction to key principles of this field.
Contents
Part I. Basic Mechanisms
Apoptosis
Henry K. Wong
Nitric Oxide
Douglas D. Thomas, Katrina M. Miranda, Deborah Citrin, Michael G. Espey, and David A. Wink
The Microcirculation and Adhesion Molecules
Thomas M. Herndon
Heat Stress
Juliann G. Kiang and David E. McClain
Immune System
Madhusoodana P. Nambiar
Complement Inhibitors in Trauma
Sherry D. Fleming
Infections
Mark E. Polhemus and Kent E. Kester
Part II. Current Concepts
Hemorrhagic Shock and Resuscitation: Trauma Research at the Trauma Research and Readiness Institute for Surgery
Peter Rhee, Hasan B. Alam, and Geoffrey S. F. Ling
Ischemia/Reperfusion Injury
Terez Shea-Donohue, Jimie Anderson, and Christopher Swiecki
Acute Respiratory Distress Syndrome
Thomas P. Shanley, Bruce Grossman, and Hector R. Wong
Thermal Injury
Leopoldo C. Cancio and Basil A. Pruitt, Jr.
Inhalation Injury
Leopoldo C. Cancio and Basil A. Pruitt, Jr.
Traumatic Brain Injury
Abel D. Jarell, James M. Ecklund, and Geoffrey S. F. Ling
Red Blood Cell Storage
John R. Hess
Bioterrorism
Michael J. Roy
Index