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Full Description
A clear and comprehensive account of how genetic abnormalities, neurobiology, and neuropsychology work together to manifest cognitive-behavioral dysfunction. The authors review the current status of research in autosomal disorders that produce cognitive-behavioral dysfunction and syndromal and nonsyndromal disorders that produce mental retardation. Comprehensive and up-to-date, Genetics and Genomics of Neurobehavioral Disorders integrates the molecular, genomic, neuropsychological, and neurobehavioral factors that produce learning disabilities and mental retardation into a coherent framework for the understanding and assessment of neurobehavioral disorders.
Contents
I. Introduction and Overview.- 1 The Genetics and Genomics of Neurobehavioral Disorders: Historical Introduction and Overview.- 2 Neuroanatomical Considerations Specific to the Study of Neurogenetics.- 3 Modeling Cognitive Disorders: From Genes to Therapies.- 4 What Can the Study of Behavioral Phenotypes Teach Us About the Pathway from Genes to Behavior?.- II. Autosomal Disorders and Neurobehavioral Dysfunction.- 5 The Central Nervous System in Neurofibromatosis Type 1.- 6 Prader—Willi and Angelman Syndromes: Cognitive and Behavioral Phenotypes.- 7 Tuberous Sclerosis.- 8 Behavioral Phenotype in Velo-Cardio-Facial Syndrome.- 9 Williams—Beuren Syndrome.- 10 Behavioral Phenotype in Myotonic Dystrophy (Steinert's Disease).- III. X-Linked Nonsyndromal Disorders and Neurobehavioral Dysfunction.- 11 Genetics of X-Linked Mental Retardation.- 12 Nonsyndromal Mental Retardation Associated with the FRAXE Fragile Site and the FMR2 Gene.- IV. X-Linked Syndromal Disorders and Neurobehavioral Dysfunction.- 13 ATR-X Syndrome.- 14 The Fragile X Syndrome and the Fragile X Mutation.- 15 Rett Syndrome: Clinical—Molecular Correlates.
