Full Description
Immunological and viral diseases of the liver have become one of the major health problems of the 21st century. In fact, the incidence and economic costs of hepatitis C now exceed those of HIV infection. Moreover, liver transplantation remains an extremely expensive therapeutic option but is often the only therapeutic option available. Over the past ten years, there have been major advances in diagnosis and treatment of immune-mediated liver pathology. Many of these diseases are mediated by viral infections; whereas others tend to be autoimmune. Some examples include infestation by the hepatitis viruses A, B, and C, as well as the immunological complications of inflammatory bowel disease such as primary sclerosing cholangitis.In this volume, the editors bring together experts in a variety of disciplines including immunologists, virologists and hepatologists to discuss the theme of liver disease from basic science through the treatment of patients. There is a heavy emphasis on understanding the best use of pharmaceuticals, the role and place of liver transplantation, and information on emerging drug treatments.
Contents
BASIC IMMUNOLOGY Lymphocyte Repertoire of the Liver Intrahepatic T Cells Role and Function of Liver Sinusoidal Endothelial Cells Intrahepatic Immune Responses in Bacterial and Parasitic Infections Intrahepatic NKT Cells in Mice and Humans Intrahepatic Dendritic Cells Mechanisms of Intrahepatic Tolerance Cytokines and Liver Diseases Mechanisms of Acute Liver Failure Antinuclear Antibodies in Liver Diseases T cells, NKT Cells and NK Cells in an Experimental Model of Autoimmune Hepatitis BACTERIAL AND VIRAL INFECTIONS Immunopathogenesis and Treatment of Hepatitis B Infection Immunopathogenesis and Treatment of Hepatitis C Infection Models of Autoimmune Liver Disease Liver Diseases AUTOIMMUNE LIVER DISEASES Genetics of Autoimmune Liver Disease Primary Biliary Cirrhosis Autoimmune Hepatitis Primary Sclerosing Cholangitis Overlap Syndromes Drug Induced Immune Mediated Liver Diseases TRANSPLANTATION Immunological Tolerance to Organ Transplants, Including Xenografts Pharmacokinetics of Immunosuppressive Drugs Diagnosis and Management of Rejection Microchimerism and Liver Transplantation Autoimmunity After Liver Transplantation
