Full Description
A clear, concise, introductory text on antibacterial agents. * Reviews the basics of bacterial structure and function, and describes the basis for understanding mechanisms of antibacterial action, as well as the mechanisms developed by bacteria to overcome the action of antibacterial agents. * Covers the characteristic features of bacterial pathogenicity, the genetic basis of resistance to antibacterial drugs, the biochemical mechanisms of action of antibacterial drugs, how antibacterial drugs reach their targets in gram-positive and gram-negative bacteria, and the wide range of human immune responses against bacterial infections. * Examines advances in research and development of new classes of antibacterial drugs. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of Contents1. Structure and Function of Prokaryotic and Eukaryotic Cells 2. Bacterial Pathogenesis 3. The Essentials of the Immune System 4. Molecular Genetics of Bacteria 5. Mechanisms of Bacterial Resistance to the Action of Antibacterial Agents 6. Antibiotics and Synthetic Antibacterial Agents 7. b-Lactams, Penicillin-Binding Proteins, and b-Lactamases 8. Inhibitors of Peptidoglycan Biosynthesis: Penicillins 9. Inhibitors of Peptidoglycan Biosynthesis: Cephalosporins 10. Inhibitors of Peptidoglycan Biosynthesis: Carbapenems and Monobactams 11. b-Lactam Compounds as b-Lactamase Inhibitors 12. Bacterial Resistance to b-Lactam Antibiotics and b-Lactam Inhibitors of b-Lactamases 13. Inhibitors of Peptidoglycan Biosynthesis: Fosfomycin and D-Cycloserine 14. Inhibitors of Peptidoglycan Biosynthesis: Bacitracin and Glycopeptides 15. Antibiotics That Affect Membrane Permeability: Cyclic Peptides 16. Antibiotic Inhibitors of Bacteria Protein Synthesis 17. Inhibitors of the 30S Ribosomal Subunit: Aminoglycosides and Tetracyclines 18. Inhibitors of the 50S Ribosomal Subunit: Macrolides, Lincosamides, and Streptogramins 19. Inhibitors of the 50S Ribosomal Subunit: Chloramphenicol 20. Inhibitors of the Formation of the First Peptide Bond: Oxazolidinones 21. Inhibitors of Isoleucyl-tRNA Synthetase: Mipirocin 22. Inhibitors of DNA-Dependent RNA Polymerase: Rifamycins 23. Inhibitors of DNA Gyrase and Topoisomerase IV: Quinolones 24. Antibacterials That Cause DNA Damage in Obligate Anaerobic Organisms: 5-Nitroimidazoles 25. Antibacterial Agents that Cause Damage to DNA: 5-Nitroimidazoles 26. Sulfonamides 27. New Antibacterial Drugs in Development That Act on Novel TargetsEpilogue Appendix A: Amino Acids, the Building Blocks of Protein Appendix B: Enzyme Catalysis and Enzyme Inhibition Lipids and Membranes Antibiotic Influx and Efflux Systems
