Full Description
Details how these proteins work while providing a review of the field. * Describes all aspects of the biology of toxins, including their synthesis and secretion from the bacterial cell, their travels to and into the target host cell, and their modes of attacking the host cell machinery. * Illustrates how bacterial toxins, each of which has distinct individual properties, often share mechanisms of secretion, membrane transport, and enzymatic action. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Contents
Table of ContentsI. Genetics and RegulationTwo Component Systems, Scott Stibitz Regulation of Bacterial Toxin Synthesis by Iron, Shelley M. Payne AraC Family Regulators and Transcriptional Control of Bacterial Virulence Determinants, Dara W. Frank and Meredith L. Hunt Quorum Sensing, Everett C. Pesci and Barbara H. IglewskiII. Toxin Biogenesis: Crossing Bacterial Membrane BarriersBox 1: Type V Export Systems, Proteins That Export Themselves, Drusilla L. BurnsThe Type I Export Mechanism, Vassilis Koronakis, Jeyanthy Eswaran, and Colin Hughes Toxins and Type II Secretion Systems, Maria E. Scott and Maria Sandkvist Type III Secretion Systems, Gregory V. Plano, Kurt Schesser, and Matthew L. NilesBox 2: Pathogenicity Islands, Jorg HackerType IV Secretion Systems, Drusilla L. BurnsIII. Toxin Delivery Into Eukaryotic CellsReceptors for Bacterial Toxins, Catharine B. SaelingerBox 3: Domain Structures of Bacterial Toxins, Stephen H. LepplaBox 4: Recombinant Immunotoxins, David J. FitzGerald, Robert J. Kreitman, and Ira PastanDirect Penetration of Bacterial Toxins Across the Plasma Membrane, Franca R. Zaretzky, Mary C. Gray, and Erik L. Hewlett Transport of Toxins Across Intracellular Membranes, Kirsten Sandvig Transcytosis of Bacterial Toxins Across Mucosal Barriers, Bonny L. Dickinson and Wayne I. LencerBox 5: Lipid Rafts, Bonny L. Dickinson and Wayne I. LencerIV. Toxin ActionMembrane-Damaging Toxins: Pore Formation, F. Gisou van der GootBox 6: The Vacuolating Toxin VacA of Helicobacter pylori, F. Gisou van der GootMembrane-Damaging Toxins: Family of RTX Toxins, Camilla Oxhamre and Agneta Richter-Dahlfors Bacterial Toxins that Covalently Modify Eukaryotic Proteins by ADP-Ribosylation, Joseph T. Barbieri and Drusilla L. BurnsBox 7: Discovery that the Active Sites of Pseudomonas aeruginosa Exotoxin A and the Heat-Labile Enterotoxin of Escherichia coli Are Superimposable, Wim HolGlucosylating and Deamidating Bacterial Protein Toxins, Klaus Aktories Plant and Bacterial Toxins as RNA N-Glycosidases, Angela Melton-Celsa and Alison D. O'Brien Cytolethal Distending Toxin, Lawrence A. Dreyfus Proteases, Ornella Rossetto, Fiorella Tonella, and Cesare MontecuccoBox 8: Landmarks in Tetanus and Botulinum Research, Ornella Rossetto, Fiorella Tonella, and Cesare MontecuccoBacterial Toxins that Modulate Rho GTPase Activity, James B. Bliska and Gloria I. Viboud Staphylococcal and Streptococcal Superantigens, Patrick M. SchlievertV. Bacterial Toxins: Friends and FoesToxins as Vaccines and Adjuvants, Mariagrazia Pizza, Vega Masignani, and Rino Rappuoli Nefarious Uses of Bacterial Toxins, Drusilla L. Burns and Joseph T. Barbieri
