Full Description
Metabolism at a Glance is a complete review course of metabolism in health and disease and offers a unique approach to the study of this difficult discipline. Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance. Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted. The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level: 1. Metabolic Channelling 2. Glucose homeostasis and Reye's Disease 3. Pentose phosphate pathway and the prodcution of NADPH 4. Tryptophan metabolism in health and disease 5. Tyrosine metabolism in health and disease
Contents
Foreword. Preface. 1 Introduction to Metabolic Pathways. 2 Biosynthesis of ATP, part I. 3 Biosynthesis of ATP, part II. 4 The oxidation of cytosolic NADH + H+. 5 Metabolism of glucose to give energy. 6 Metabolism of one molecule of glucose to form 38 molecules of ATP. 7 Metabolism of glucose to glycogen. 8 Anaerobic metabolism of glucose and glycogen to yield energy as ATP. 9 2,3 Bisphosphoglycerate and the red blood cell. 10 Metabolism of glucose to fat (triacylglycerol). 11 Metabolism of glucose to fatty acids and triacylglycerol. 12 The pentose phosphate pathway and the production of NADPH. 13 The pyruvate/malate cycle and the production of NADPH. 14 Mammals cannot synthesis glucose from fatty acids. 15 Metabolism of triacylglycerol to provide energy as ATP. 16 Glycogen metabolism part I. 17 Glycogen metabolism part II. 18 Glycogen metabolism part III: regulation of glycogen breakdown. 19 Glycogen metabolism part IV : regulation of glycogen biosynthesis. 20 Regulation of glycolysis. 21 Glycolysis and the pentose phosphate pathway in the liver in the fed state. 22 Glycolysis in skeletal muscle; biochemistry of sport and excerise. 23 Regulation of gluconeogenesis. 24 Regulation of the Krebs cycle. 25 Regulation of fatty acid oxidation part I. 26 Regulation of fatty acid oxidation part II. 27 The ketone bodies. 28 Ketone body utilisation. 29 Beta-Oxidation of unsaturated fatty acids. 30 Peroxisomal Beta-oxidation. 31 Elongation and desaturation of fatty acids. 32 Cholestrerol, bile acids and the steroid hormones. 33 The ornithine cycle for the production of urea. 34 Metabolic Channelling. 35 Biosynthesis of the non-essential amino acids. 36 Catabolism of amino acids. 37 Catabolism of amino acids. 38 Metabolism of amino acids to glucose in starvation and during the period immediately after re-feeding. 39 Metabolism of protein to fat. 40 Disorders of amino acid metabolism. 41 Tyrosine metabolism in health and disease. 42 Tyrosine metabolism. 43 Amino acid metabolism, folate metabolism and the 1-carbon pool part I. 44 Amino acid metabolism, folate metabolism and the 1-carbon pool part II. 45 Porphyrin metabolism, heam and the bile pigments. 46 Metabolism of ethanol. 47 Sorbitol, galactitol, glucaronate and xylitol. 48 Fructose metabolism. 49 Glucose homeostasis: Reye's syndrome. 50 Diabetes I: insulin-stimulated glycogen synthesis. 51 Diabetes II: metabolic changes in Type I diabetes. 52 Diabetes III: Type I diabetes, type II diabetes, MODY and pancreatic Beta-cell metabolism. 53 Diabetes IV: type II diabetes and insulin resistance in muscle. 54 Diabetes V: type II diabetes and insulin resistance in adipose tissue. 55 Diabetes VI: type II diabetes and insulin resistance in liver. Index.
