Full Description
The individual chapters in this book combine to form components of a detailed story of the local and systemic pathophysiology of intestinal inflammation, with a series of management strategies. The authors present research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders. This book blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease. This book is designed to illustrate the effectiveness of a team approach of basic scientists and clinician investigators in this field. It will give the reader a glimpse of where the field is moving and an idea of likely research directions in the future.
Contents
Preface. Section 1: The Laboratory Bench. 1. Overview of Inflammatory Bowel Diseases: From Bench to Bedside and Back; F. Shanahan, et al. 2. The Changing Faces of Crohn's Disease and Ulcerative Colitis; A. Ekbom. 3. Genetics of Inflammatory Bowel Disease; J.I. Rotter, H. Yang. 4. Animal Models of Inflammatory Bowel Disease; C.O. Elson. 5. The Normal Intestinal Mucosa - A State of `Controlled' Inflammation; C. Fiochi. 6. The Bacterial/Epithelial/Lymphocyte Interface; R. Blumberg. 7. The Mucosal Inflammatory Response I: Cytokines and Chemokines; F. Cominelli. 8. The Mucosal Inflammatory Response II: Inflammatory Mediators; M. Grisham. 9. Remission, Relapse, Intestinal Healing and Repair; D. Podolsky. 10. Antibodies in Inflammatory Bowel Disease: The hunt of pathogens and antigens, and their role in disease stratification and disease course prognosis; J. Braun. 11. Effect of Inflammation on Intestinal Function; S. Collins. 12. Systemic Consequences of Intestinal Inflammation; M.T. Abreu-Martin. Section II: The Bedside. 13. Explaining the Signs and Symptoms of Inflammatory Bowel Diseases; F. Shanahan, et al. 14. Clinical Course and Complications of Ulcerative Colitis and Ulcerative Proctitis; L. Sutherland. 15. Clinical Features and Complications of Crohn's Disease; W. Tremaine. 16. Mechanisms of Extraintestinal Manifestations; R. Balfour Sartor. 17. Pathology of Inflammatory Bowel Diseases: A Clinical Appraisal in Diagnosis and Management; K. Lewin. 18. An Endoscopist's Perspective of Diagnosis: When, Where and What to Do; C. Bernstein, W. Weinstein. 19. Radiologic/Radiographic Features of Ulcerative Colitis and Crohn's Disease; E. Fitzgerald. 20. New Diagnostic Approaches; L. Kam, E. Vasiliauskas. 21. Differential Diagnosis of Colitis; C. Surawicz. 22. Inflammatory Bowel Disease in the Era of Managed Care; D. Alpers. 23. Pharmaco Economic Outcomes/Disease Activity Indices/ Study Design; B. Feagan. 24. Quality of Life Issues and Disease Activity Indices; E.J. Irvine. 25 Additional Chapters. Section III: Back to the Laboratory Bench. 50. Epilogue; S.R. Targan.
