Full Description
Leading clinicians and clinical researchers discuss in practical detail the newest treatments used in rheumatic diseases, emphasizing-without neglecting current standard treatments-those experimental therapies now undergoing clinical trials and poised for early introduction into the rheumatology armamentarium. The diseases and therapeutic regimes examined here range from rheumatoid arthritis and its treatment by gene therapy, to osteoarthritis and systemic autoimune diseases. Each chapter is organized so that the busy clinician can quickly obtain all the information needed optimal patient treatment. This includes an analysis of the pathogenic mechanisms that explain the molecular basis of the newer therapeutics, reviews of animal data and the results of clinical trials, and recommendations concerning use, side effects, and precautions.
Contents
I. Rheumatoid Arthritis
Larry W. Moreland, Section Editor
New Treatment Opportunities for Rheumatoid Arthritis
Larry W. Moreland
Genetic Influences on Treatment Response in Rheumatoid Arthritis
S. Louis Bridges, Jr. and Robert P. Kimberly
Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis
John S. Sundy
Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs
M. Elaine Husni and Lee S. Simon
Glucocorticoid Therapy in Rheumatoid Arthritis
Kenneth G. Saag and John R. Kirwan
Anti-Tumor Necrosis Factor Agents
Alan K. Matsumoto and Joan M. Bathon
Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis
Barry Bresnihan
Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis
Paul Emery, David L. Scott, and Vibeke Strand
Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis
Sean J. Wollaston and Kenneth C. Kalunian
Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy
James R. O'Dell
Experimental Therapeutics for Rheumatoid Arthritis
Mark C. Genovese and William H. Robinson
II. Osteoarthritis
Jean-Pierre Pelletier and Johanne Martel-Pelletier, Section Editors
Slow-Acting Drugs for the Treatment of Osteoarthritis
Jean-Yves Reginster and Roy D. Altman
Intra-Articular Therapy in Ostheoarthritis
Boulos Haraoui and Jean-Pierre Raynauld
Promoting Articular Cartilage Repair
Joseph A. Buckwalter and James A. Martin
Using Molecular Markers to Monitor Osteoarthritis
Ivan G. Otterness and Mary J. Saltarelli
New Therapeutic Targets for Osteoarthritis: The Rewards of Research
Jean-Pierre Pelletier, Johanne Martel-Pelletier, and Pamela Manning
Recent Developments in the Therapy of Osteoarthritis
Jean-Pierre Pelletier and Johanne Martel-Pelletier
III. Systemic Autoimmune Diseases
Gary M. Kammer and George C. Tsokos, Section Editors
Treatment of Systemic Lupus Erythematosus
Peter H. Schur and Gary M. Kammer
Treatment of the Antiphospholipid Syndrome
Joan T. Merrill
Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation
David I. Daikh and David Wofsy
Current Management of Systemic Sclerosis
Clarence W. Legerton III and Richard M. Silver
Sjögren's Syndrome
Robert W. Hoffman and Eric L. Greidinger
Mixed Connective Tissue Disease
Robert W. Hoffman and Eric L. Greidinger
Vasculitis
Dimitrios Vassilopoulos and Leonard H. Calabrese
Treatment of Juvenile Rheumatoid Arthritis
Laura J. Mirkinson and Ildy M. Katona
Treatment of Inflammatory Myopathies
William R. Gilliland
Psoriatic Arthritis
Dimitrios T. Boumpas and Gabor G. Illei
Complement Inhibitors in Rheumatic Diseases
Sherry D. Fleming and George C. Tsokos
Hematopoietic Stem Cell Transplantation of Autoimmune Disease
Richard K. Burt and Ann E. Traynor
IV. Gene Therapy in Rheumatic Diseases
Steffen Gay, Section Editor
Vectors for Gene Delivery
Sandro Rusconi and Maurizio Ceppi
Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model
Jörg Schedel, Thomas Pap, Ulf Müller-Ladner, Renate E. Gray, and Steffen Gay
Retroviral Transduction of Antigen-Specific CD4+ T Cells for Local Delivery of Regulatory Molecules
Gina L. Costa and C. Garrison Fathman
Gene Transfer to Lymphocytes Targeting Cartilagineous Collagen Type II
Alexander E. Annenkov and Yuti Chernajovsky
Gene Therapy in Murine Arthritis:
