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Full Description
"Neurons in Action" tutorials are CD-ROM-based learning tools that combine text with computer simulations of laboratory experiments in neurophysiology. Using the professional research simulator NEURON, developed at Duke and Yale Universities, students discover how changing parameters such as neuronal geometry, ion concentrations, and ion conductances affect the generation of potentials, synaptic potentials, and the spread of propagation of voltages within a neuron. With its novel use of interactive movies, the CD allows the student to visualize changing voltage patterns not only in time, but in space, providing insight into nerve function that is simply not possible with conventional text and figure presentations. Because "Neurons in Action" documents are written in HTML format and displayed by an Internet browser, the student can make extensive use of hyperlinks to answer questions raised by the tutorials and to extend the information supporting the experiments.
Contents
Introduction to NeuroLab; about NeuroLab - what is NeuroLab?; how does NeuroLab run simulations?; unique advantages of these simulations; NeuroLab's background in computational neuroscience; NeuroLab's cellular descriptions; orientation; how to navigate in NeuroLab; how to operate NeuroLab's control panels and graphical windows; how to make presentations containing NeuroLab figures. Local potentials in a cell soma or uniform patch of membrane: level I resting potential action potential; level II voltage clamp threshold refractoriness; level III the postsynaptic potential interactions of postsynaptic potentials. Voltage spread in uniform axons: level I passive axons unmyelinated axons myelinated axons. Impulse propagation under non-uniform conditions: level I partial demyelination - the multiple sclerosis problem; level II change in diameter nonuniform channel density; level III the presynaptic terminal. Impulse generation in cells: level III site of impulse initiation spatial and temporal integration of synaptic inputs on dendrites. Appendices: help equations - Nernst, Hodgkin-Huxley membrane components and characteristics; how membrane currents were sorted out; temperature, threshold and impulse propagation.
