興奮性膜のイオンチャンネル（第３版）<br>Ion Channels of Excitable Membranes （3TH）

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興奮性膜のイオンチャンネル（第３版）
Ion Channels of Excitable Membranes （3TH）

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  • 製本 Hardcover:ハードカバー版／ページ数 814 p.
  • 言語 ENG
  • 商品コード 9780878933211
  • DDC分類 571064

基本説明

１０年振りの改訂版。
Describes the known channels and their physiological functions, develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics

Full Description


This fully revised and expanded Third Edition of Ionic Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. Ionic Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognised authoritative overview of this field used by all neuroscientists.

Contents

PART I.- Classical biophysics of the squid giant axon.- The superfamily of voltage-gated channels.- Voltage-gated calcium channels.- Potassium channels and chloride channels.- Ligand-gated channels of fast chemical synapses.- Modulation, slow synaptic action, and second messengers.- Sensory transduction and excitable cells.- Calcium dynamics, epithelial transport, and intercellular coupling.- PART II.- Elementary properties of ions in solution.- Elementary properties of pores.- Counting channels.- Structure of channel proteins.- Selective permeability: Independence.- Selective permeability: Saturation and binding.- Classical mechanisms of block.- Structure-function studies of permeation and block.- Gating mechanisms: Kinetic thinking.- Gating: Voltage sensing and inactivation.- Modification of gating in voltage-sensitive channels.- Cell biology and channels.- Evolution and origins.