基本説明
Features examples from numerous areas of medicine, including cardiovascular diseases, neurological diseases, cancer, and AIDS.
Full Description
From aspects of early trials to complex modeling problems, Advances in Clinical Trial Biostatistics summarizes current methodologies used in the design and analysis of clinical trials. Its chapters, contributed by internationally renowned methodologists experienced in clinical trials, address topics that include Bayesian methods for phase I clinical trials, adaptive two-stage clinical trials, and the design and analysis of cluster randomization trials, trials with multiple endpoints, and therapeutic equivalence trials. Other discussions explore Bayesian reporting, methods incorporating compliance in treatment evaluation, and statistical issues emerging from clinical trials in HIV infection.
Contents
Bayesian Methods for Cancer Phase I Clinical TrialsJames S. Babb and Andre Rogatko Design of Early Trials in Stem Cell Transplantation: A Hybrid Frequentist-Bayesian Approach Nancy L. Geller, Dean Follmann, Eric S. Leifer, and Shelly L. Carter Design and Analysis of Therapeutic Equivalence Trials Richard M. Simon Adaptive Two-Stage Clinical Trials Michael A. Proschan Design and Analysis of Cluster Randomization TrialsDavid M. Zucker Design and Analysis of Clinical Trials with Multiple EndpointsNancy L. Geller Subgroups and InteractionsDean Follmann A Class of Permutation Tests for Some Two-Sample Survival Data ProblemsJoanna H. Shih and Michael P. Fay Bayesian Reporting of Clinical TrialsSimon Weeden, Laurence S. Freedman, and Mahesh Parmar Methods Incorporating Compliance in Treatment Evaluation Juni Palmgren and Els Goetghebeur Analysis of Longitudinal Data with MissingnessPaul S. Albert and Margaret C. Wu Statistical Issues Emerging from Clinical Trials in HIV InfectionAbdel Babiker and Ann Sarah Walker
