基本説明
Focuses exclusively on animal-based experimental approaches to improve current diagnostic and therapeutic practices in the management of sleep-related breathing disorders.
Full Description
Systematically assessing the relative strengths and weaknesses of various animal model systems, this reference presents an overview of the known pathophysiology of sleep-related breathing disorders. It focuses exclusively on animal-based experimental approaches to improve current diagnostic and therapeutic practices in the management of these disorders. Providing a fundamental understanding of sleep-related breathing disorders, the book introduces sleep disorders and applies modern neuroscience to regulation of breathing during sleep. The authors have collected nearly all known studies, summarized the date, and provided easy to understand diagrams, charts, and figures.
Contents
Overview: pathophysiology of sleep-related breathing disorders in man - unanswered questions. General techniques: instrumentation and methods for chronic studies of sleep and breathing in rodents; neurochemical evidence for the cholinergic modulation of sleep and breathing; functional anatomical analysis of respiratory circuitry; gene and protein expression and regulation in the central nervous system. Experimental sleep-related breathing disorders: intermittent hypoxia; computer-controlled airway occlusion. Naturally occurring sleep-related breathing disorders: the pre-term lamb - a unique animal model of neonatal respiratory instability; neonatal rat; mature rat; English bulldog; aquatic mammals.
