基本説明
Suggests that major chronic diseases in adult life may be prevented by improving the nutrition of girls and young women to promote health fetal development during pregnancy.
Full Description
This watershed reference presents epidemiological, clinical, and experimental evidence that cardiovascular disease, Type 2 diabetes, and chronic lung disease originate through adaptations to the intrauterine environment. These new findings suggest that major chronic diseases in adult life may be prevented by improving the nutrition of girls and young women to promote healthy fetal development during pregnancy.Focusing on prenatal programming-the process whereby stimuli or insults at critical early periods of life have lasting effects-Fetal Origins of Cardiovascular and Lung Disease demonstrates the associations between low birthweight and cardiovascular disease and Type 2 diabetes in adults reveals the association between prenatal influences and hypertension and asthma in adult life describes pancreatic development in the fetus when the mother is malnourished or experiences metabolic disturbances during pregnancy examines the effects of undernutrition during gestation in experimental animal models discusses how the human fetus adapts to variations in maternoplacental nutrient supply details fetal influences on lipid metabolism, insulin sensitivity, the somatotrophic axis, andrenarche, and pubarche and more!Investigating when nurturing begins to influence and modulate gene expression, Fetal Origins of Cardiovascular and Lung Disease is critical for pulmonologists, cardiologists, pediatricians, neonatologists, obstetricians, internists, family practice physicians, and hospital interns and residents.
Contents
IntroductionDavid J. P. BarkerBirth Weight, Blood Pressure, and Hypertension: Epidemiological StudiesDavid A. Leon and Ilona KoupilovaMechanisms for In Utero Programming of Blood PressureChristopher N. Martyn and Stephen E. GreenwaldLow Birth Weight and the Emerging Burden of Renal Disease in the United StatesDaniel T. Lackland, Holly E. Bendall, Clive Osmond, and Brent M. EganIntrauterine Nutrition: Its Importance During Critical Periods for Cardiovascular and Endocrine DevelopmentJoseph J. Hoet and Mark A. HansonPhysiological Development of the Cardiovascular System In UteroKent L. ThornburgNon-Insulin-Dependent Diabetes and ObesityDavid I. W. PhillipsMetabolic Alterations After Early Growth RetardationSusan Ozanne, B. J. Jennings, and C. Nicholas HalesGrowth, Metabolic, and Endocrine Adaptations to Fetal UndernutritionJane E. Harding and Peter D. GluckmanThe Role of Hormones in Intrauterine DevelopmentAbigail L. Fowden and Alison J. ForheadThe Hypothalamic-Pituitary-Adrenal and Hypothalamic-Pituitary-Gonadal Axes in Early Life: Problems and PerspectivesStephen G. Matthews, David I. W. Phillips, John R. G. Challis, David B. Cox, Eric Jackson Thomas, Caroline McMillen, S. J. Lye, Roger B. McDonald, E. Marelyn Wintour, Janna L. Morrison, and Deborah M. SlobodaReduced Fetal Growth and Pediatric EndocrinopathiesFrancis de Zegher, Inge Francois, and Lourdes IbanezMaternal Nutrition and Fetal Development: Implications for Fetal ProgrammingKeith M. GodfreyMaternal and Placental Influences that Program the Fetus: Experimental FindingsJeffrey S. Robinson, Caroline McMillen, Lisa Edwards, Karen Kind, Kathryn L. Gatford, and Julie OwensFetal Origins of Lung DiseaseJohn O. Warner and Catherine A. JonesThe Nutrition Transition and its Implications for the Fetal Origins HypothesisBarry M. PopkinEffects of Maternal Nutrition and Metabolism on the Developing Endocrine Pancreas: Experimental FindingsB. Reusens and C. Remacle
