基本説明
"This book is written by experts in the field and focuses on both HIV therapy and prevention. It is well illustrated, highly informative, and provides authoritative and completely up-to-date accounts of a complex subject... - Robert C. Gallo, Institute of Human Virology.
Full Description
The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent. These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research.
The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients. Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Gotte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang.
Contents
Preface vii Contributors xi Chapter 1 The Structure and Biology of HIV 1: Introduction by Elana Cherry and Mark A. Wainberg Chapter 2 The Genetics of HIV-1 by Jon P. Anderson, Matthew Rain, Daniel Shriner, Allen G. Rodrigo, Yang Wang, David Nickle, Gerald H. Learn, Willscott E. Naugler, and James I. Mullins 44 Chapter 3 Nucleoside Inhibitors of HIV Reverse Transcriptase and the Problem of Drug Resistance by Matthias Gdtte, Shalom Spira, and Mark A. Wainberg 100 Chapter 4 Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1 by Jan Balzarini 132 Chapter 5 HIV -1 Protease Inhibitors by Jon H. Condra and Joseph P. Vacca 172 Chapter 6 The Biology and Biochemistry of Integration as a Target for Chemotherapeutic Intervention by Daria J. Hazuda 223 Chapter 7 Chemokine Receptors in HIV Infection and AIDS by Nathaniel R. Landau 250 Chapter 8 Novel HIV-1 Therapeutic Targets: Regulatory Functions by Catherine Ulich and Richard B. Gaynor 294 Chapter 9 Novel HIV -1 Therapeutic Targets: Accessory Functions by Mario Stevenson 328 Chapter 10 The Interface between the Pathogenesis and Treatment of HIV Infection by Mark B. Feinberg 384 Chapter 11 HIV Prevention: Implementing Proven Prevention Interventions to Control the Global Epidemic by Chris Collins, Todd Summers, and Tom Coates 441 Chapter 12 The Immunobiology of HIV -1 Infection by Norman L. Letvin 459 Chapter 13 HIV Vaccines 2000: Prospects and Challenges by Spyros A. Kalams and Bruce D. Walker 481 Index 511
