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Full Description
This title is a greatly expanded and updated second edition of the original volume published by Elsevier in 1986. New material has been integrated with the original content in an organized and comprehensive manner. Five new chapters have been included, which review over one and a half decades of research into lipid-coated microbubbles (LCM) and their medical applications. The new chapters contain much experimental data, which is examined in detail, along with relevant current literature. This current edition builds on the original work in effectively filling the gap in the market for a comprehensive account of the surfactant stabilization of coated microbubbles. It presents updated results from extensive multidisciplinary research on coated microbubbles. It is greatly expanded and updated 2nd edition, with five new chapters. It fills the gap for a comprehensive and up-to-date account of subject matter.
Contents
Occurrence of dilute gas-in-liquid emulsions in natural waters; Early work with aqueous carbohydrate gels; Comparison of aqueous soil extracts with carbohydrate gels; Characteristic glycopeptide fraction of natural microbubble surfactant; Ecological chemistry of microbubble surfactant; Surface properties of microbubble surfactant monolayers; Structure of predominant surfactant components stabilizing natural microbubbles; Stable microbubbles in physiological fluids - competing hypotheses; Concentrated gas-in-liquid emulsions in artificial media I Demonstration by laser-light scattering; Concentrated gas-in-liquid emulsions in artificial media II Characterization by photon correlation spectroscopy; Concentrated gas-in-liquid emulsions in artificial media III Review of molecular mechanisms involved in microbubble stabilization; Targeted imaging of tumors, and targeted cavitation therapy, with lipid-coated microbubbles (LCM); Targeted drug-delivery therapy of tumors using LCM; Proposed mechanism of selective LCM uptake by tumor cells - role of lipoprotein receptor-mediated endocytic pathway; Endocytotic events versus particle size - multidisciplinary analyses demonstrate LCM - sizes are mostly submicron.
