基本説明
"Frontiers in Animal Diabetes Research"
Full Description
Type II diabetes has developed into a global epidemic, with nearly 20 type II patients for every type I individual. Preceding the onset of type II diabetes is a prolonged episode of insulin resistance featuring a host of detrimental symptoms. This period comprises a disease referred to as Insulin Resistance Syndrome or Metabolic Syndrome. Insulin Resistance and Insulin Resistance Syndrome deals with the cellular and whole body pathogenic mechanisms and phenotypic expressions in various models of insulin resistance. Leaders in the field provide their perspectives on the mechanisms of insulin resistance, as observed in various animal models. While the exact mechanism underlying resistance to insulin is unknown, the authors review many of the significant factors. A series of chapters on Metabolic Syndrome discusses its possible insulin resistance-associated pathophysiology with obesity, cardiovascular disease, hypertension, glucose intolerance, and abnormalities in whole body metabolism. Presenting essential knowledge in the field of insulin resistance, this book will benefit clinicians, pharmaceutical scientists, and researchers involved in endocrinology, biochemistry and metabolism in diabetes.
Contents
METABOLISM AND HYPERTENSION Insulin Resistance Syndrome and Glycogen Synthesis, Roles of Muscle, Liver and Adipose Tissue, Hagit Eldar-Finkelman and Merav Yarkoni Hypertension and Insulin Resistance in the SJHR-Koletsky Rats, Jianhua Shao and Jacob Friedman Role of PTPase in Insulin Action and Insuln Resistance; Recent Insights from Cellular and Animal Studies, Barry Goldstein Hypertension and Insulin Resistance in the Wistar Fatty Rat, M. Suzuki, H. Odaka and Y. Sugiyama Cardiovascular Disease in Insulin-Resistant, Atherosclerosis-Prone JCR:LA-cp Rat, J.C. Russell and S.E. Kelly The C57/BL6J Mouse as a Model of Insulin Resistance and Hypertension, Tonya Martin-Dixon, Sheila Collins and Richard Surwitt MOLECULAR AND GENETIC Molecular Features of Insulin Resistance, Obesity and Diabetes in Non-Human Primates, S.V. Angeloni and B.C. Hansen Altering Gene Expression to Study Insulin Sensitivity, Maureen J. Charron, et al. Access to Genes Involved in the Etiology of Insulin Resistance, G.R. Collier, et al. Insulin Signaling Pathway and GLUT4-Mediated Glucose Transport in Insulin Resistance Muscle, Amira Klip, et al. Leptin and Insulin Resistance, Kevin Stark Fat Feeding and Muscle Fat Disposition Eliciting Insulin Resistance, E.W. Kraegen, et al. D-chiro-inositol and Insulin Resistance: An Allosteric Point of View, Joseph Larner GPL-1 Exendin and Insulin Sensitivity, Andrew Young Insulin Resistance and the Autonomic Nervous System, L. Penicaud, et al. Hypothalmic Role in the Insulin Resistance Syndrome, Anthony Cincotta Insulin Resistance - Emerging Therapies for Affected Sites, Julie Moyers and Jose Caro AGING Effect of Age on the Emergence of Insulin Resistance, Nir Barzilai and Ilan Gabriely Postnatal and Adulthood Effects on the Metabolism and Sensitivity of Progeny of Perinatally Compromised Mothers, C.N. Hales, et al.
