遺伝子解析のための数理・統計法（第２版）<br>Mathematical and Statistical Methods for Genetic Analysis (Statistics for Biology and Health) （2nd ed. 2002. XII, 265 p. 24 cm）

個数：
  • ポイントキャンペーン

遺伝子解析のための数理・統計法（第２版）
Mathematical and Statistical Methods for Genetic Analysis (Statistics for Biology and Health) （2nd ed. 2002. XII, 265 p. 24 cm）

  • ウェブストア価格 ¥25,043（本体¥22,767）
  • SPRINGER, BERLIN（2002発売）
  • 外貨定価 US$ 129.99
  • ゴールデンウィーク ポイント2倍キャンペーン対象商品(5/6まで)
  • ポイント 454pt
  • 提携先の海外書籍取次会社に在庫がございます。通常3週間で発送いたします。
    【重要ご説明事項】
    1. 納期遅延や、ご入手不能となる場合が若干ございます。
    2. 複数冊ご注文の場合、分割発送となる場合がございます。
    3. 美品のご指定は承りかねます。
  • 【入荷遅延について】
    世界情勢の影響により、海外からお取り寄せとなる洋書・洋古書の入荷が、表示している標準的な納期よりも遅延する場合がございます。
    おそれいりますが、あらかじめご了承くださいますようお願い申し上げます。
  • ◆画像の表紙や帯等は実物とは異なる場合があります。
  • ◆ウェブストアでの洋書販売価格は、弊社店舗等での販売価格とは異なります。
    また、洋書販売価格は、ご注文確定時点での日本円価格となります。
    ご注文確定後に、同じ洋書の販売価格が変動しても、それは反映されません。
  • 製本 Hardcover:ハードカバー版／ページ数 361 p.
  • 商品コード 9780387953892

基本説明

Expands the original edition by over 100 pages and includes new material on DNA sequence analysis, diffusion processes, binding domain identification, Bayesian estimation of haplotype frequencies, case-control association studies, and more.

Full Description

During the past decade, geneticists have cloned scores of Mendelian disease genes and constructed a rough draft of the entire human genome. The unprecedented insights into human disease and evolution offered by mapping, cloning, and sequencing will transform medicine and agriculture. This revolution depends vitally on the contributions of applied mathematicians, statisticians, and computer scientists. Mathematical and Statistical Methods for Genetic Analysis is written to equip students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand in hand with applications to population genetics, gene mapping, risk prediction, testing of epidemiological hypotheses, molecular evolution, and DNA sequence analysis. Many specialized topics are covered that are currently accessible only in journal articles. This second edition expands the original edition by over 100 pages and includes new material on DNA sequence analysis, diffusion processes, binding domain identification, Bayesian estimation of haplotype frequencies, case-control association studies, the gamete competition model, QTL mapping and factor analysis, the Lander-Green-Kruglyak algorithm of pedigree analysis, and codon and rate variation models in molecular phylogeny. Sprinkled throughout the chapters are many new problems.

Contents

Basic Principles of Population Genetics.- Counting Methods and the EM Algorithm.- Newton's Method and Scoring.- Hypothesis Testing and Categorical Data.- Genetic Identity Coefficients.- Applications of Identity Coefficients.- Computation of Mendelian Likelihoods.- The Polygenic Model.- Descent Graph Models.- Molecular Phylogeny.-  Radiation Hybrid Mapping.- Models of Recombination.- Sequence Analysis.- Poisson Approximation.- Diffusion Processes.