I Domains in Integrins (Molecular Biology Intelligence Unit)

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I Domains in Integrins (Molecular Biology Intelligence Unit)

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  • 製本 Hardcover:ハードカバー版／ページ数 200 p.
  • 言語 ENG
  • 商品コード 9780306478369
  • DDC分類 572.68

基本説明

The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease.

Full Description

In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.
This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.

Contents

Preface. 1. Evolution of Integrin I-Domains; M.S. Johnson, D. Tuckwell. 2. Integrin alpha1beta1; H. Gardner. 3. Function of alpha2beta1 Integrin; M.M. Zutter, S.A. Santoro. 4. Structure Distribution and Function of alpha10beta1 Integrin; E. Lundgren-Akerlund, M. Schneller. 5. Structure and Function of alpha11beta1 Integrin; D. Gullberg, S.N. Popova, C.-F. Tiger. 6. Structure and Activation of beta2-Integrins; C.G. Gahmberg, S. Fagerholm. 7. Integrin alphaEbeta7: Molecular Features and Functional Significance in the Immune System; P.J. Kilshaw, J.M.G. Higgins. 8. Structural Aspects of Integrins; R.C. Liddington. 9. Integrin Recognition Motifs in Collagens; R.W. Farndale. 10. Cellular Signaling by Collagen-Binding Integrins; J. Heino. 11. Collagen-Binding Integrins and Disease; B. Eckes, B. Nieswandt, T. Krieg. 12. Integrins in Immune and Inflammatory Disease; A.R. de Fougerolles. Index.