Full Description
This volume is comprised of the majority of lecture presentations and a few select posters presented at the International Workshop, "Basal Ganglia and Thalamus in Health and Movement Disorders," held in Moscow, Russia, on May 29-31, 2000. The International Committee responsible for organizing this workshop included Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of Medical Sciences, Mahlon DeLong, Chair, Department of Neurology, Emory University, Atlanta, USA, Alim Louis Benabid, Chief, Neurosurgery Service, University of Joseph Fourrier, Grenoble, France, and the two undersigned. The workshop was conceived out of a desire to provide a forum for discussions of both basal ganglia-and motor thalamus-related issues by bringing together basic scientists and clinicians representing different disciplines, research directions, and philosophies. The primary goals were to encourage an exchange of information and ideas in an informal environment, to stimulate integration of the data from different disciplines, and to identifY controversial issues and the most essential questions to be addressed in future research.
Contents
Part I: Basal Ganglia Circuitry in Movement Disorders: Historical Perspective and Overview of the Current Status of the Field. What We Know and What We Have Left to Learn; A.B. Young, J.B. Penney. Basal Ganglia Circuits in Movement and Movement Disorders; T. Wichmann, M. DeLong. Part II: Anatomical and Functional Organization of Basal Ganglia and Motor Thalamic Circuits. Microcircuits of the Striatum; J.P. Bolam, M.D. Bevan. Local and Efferent Neurons and Intrinsic Modular Arrangement of the Human Striatum; T. Leontovich. Efferent Connections of the Human Striatum and Pallidum: A Nauta Degeneration Study; A. Morel, et al. Cognitive Aspects of the Motor Function of the Striatum; B.F. Tolkunov, et al. Neuroanatomical Organization and Connections of the Motor Thalamus in Primates; I.A. Ilinsky, K. Kultas-Ilinsky. Pallidal and Cortical Determinants of Thalamic Activity; M.E. Anderson, et al. Physiological Evidence for Spinal Cord Input to the Motor Thalamus; R. Mackel. Part III: Neurotransmitters, Receptors and Their Role in Motor Behavior. Chemical Anatomy and Synaptic Connectivity of the Globus Pallidus and Subthalamic Nucleus; Y. Smith, et al. Effects of Dopamine Receptor Stimulation on Basal Ganglia Activity; J.R. Walters, et al. Physiological Roles of Multiple Metabotropic Glutamate Receptor Subtypes in the Rat Basal Ganglia; P.J. Conn, et al. Muscarinic Receptors of the Dorsal Striatum: Role in Regulation of Motor Behavior; K. Shapovalova. Part IV: Movement and Sleep Disorders as Related to Basal Ganglia-Thalamic Circuits. Functional Organization of Brainstem-Basal Ganglia Interactions as Viewed From the Pedunculopontine Region; G.L. Keating, D.B. Rye. Fatal Familial Insomnia: A Disease Model Emphasizing the Role of the Thalamus in the Regulation of the Sleep-Wake Cycle and Other Circadian Rhythms; P. Avoni, et al. Part V: Plasticity in Movement Disorders. Plasticity and Basal Ganglia Disorders; M. Hallet. Mechanisms of Subthalamic Dysfunction in Parkinson's Disease; M.-F. Chesselet, et al. Neurotransmitters and Receptors in the Primate Motor Thalamus and Potential for Plasticity; K. Kultas-Ilinsky, I.A. Ilinsky. Microelectrode Studies of Basal Ganglia and VA, VL and VP Thalamus in Patients with Dystonia: Dystonia-Related Activity and Somatic Sensory Reorganization; F.A. Lenz, et al. Part VI: Neuronal Activity in Movement Disorders. Physiology of Globus Pallidus Neurons in Movement Disorders; M. Filion. Physiology of Subthalmic Nucleus Neurons in Animal Models of Parkinson's Disease; A. Benazzouz, et al. The Motor Thalamus: Alteration of Neuronal Activity in the Parkinsonian State; C. Elder, J. Vitek. Neuronal Activity In Motor Thalamus of Parkinson's Disease Patients; J.O. Dostrovsky, et al. Electrophysiological Insights Into the Motor Control System in Parkinsonism; S. Raeva. Behavior of Thalamic Neurons in the Movement Disorders - Tremor and Dystonia; C. Ohye, T. Shibazaki. The Motor Control Output Forming in Healthy Subjects and Parkinson's Disease Patients; S. Romanov, M.G. Pchelin. Part VII: Mechanisms and Efficiency of Novel Treatments for Movement Disorders. How Are We Inhibiting Functional Targets with High Frequency Stimulation? A.L. Benabid, et al. Is There a Single Best Surgical Procedure for the Alleviation of Parkinson's Disease? T. Aziz, et al. Thalamic Surgery for Tremor; A. Lozano, et al. What is the Influence of Subthalamic Nuc
