人体中のプリン・ピリミジンの代謝(会議録)<br>Purine and Pyrimidine Metabolism in Man X (Advances in Experimental Medicine and Biology)

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人体中のプリン・ピリミジンの代謝(会議録)
Purine and Pyrimidine Metabolism in Man X (Advances in Experimental Medicine and Biology)

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  • 製本 Hardcover:ハードカバー版/ページ数 424 p.
  • 言語 ENG
  • 商品コード 9780306465154
  • DDC分類 616.39043

基本説明

The main topics covered are: Normal metabolism of purines and pyrimidines; the inborn errors of purine and pyrimidine metabolism; purinergic signaling; chemotherapy with purine and pyrimidine analogues, and more.

Full Description

th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.

Contents

Inborn Errors of Purine Metabolism.- Purine Metabolism.- Gout and Hyperuricemia.- Purines in Cardiology.- Renal Handling of Purines.- Purinergic Signalling.- Inborn Errors of Pyrimidine Metabolism.- Pyrimidine Metabolism.- Oncology and Chemotherapy.- Methods.