基本説明
神経細胞の生物学を網羅した最新研究書の改訂版。
Explains how the latest breakthroughs in genomic mapping and imaging techniques have illuminated the mechanisms by which a neuron generates varied patterns of electrical activity and transfers this information to other neurons.
Full Description
The third edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The first part of the book covers the properties of the many newly discovered ion channels that have emerged through mapping of the genome. These channels shape the way a single neuron generates varied patterns of electrical activity. Next are covered the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The second part of the book covers the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells which transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory.
Contents
I. INTRODUCTION ; 1. Signaling in the Brain ; 2. Form and Function in Cells of the Brain ; II. ELECTRICAL PROPERTIES OF NEURONS ; 3. Electrical Signaling in Neurons ; 4. Membrane Ion Channels and Ion Currents ; 5. Ion Channels are Membrane Proteins ; 6. Ion Channels, Membrane Ion Currents, and the Action Potential ; 7. Diversity in the Structure and Function of Ion Channels ; III. INTERCELLULAR COMMUNICATION ; 8. How Neurons Communicate: Gap Junctions and Neurosecretion ; 9. Synaptic Release of Neurotransmitters ; 10. Neurotransmitters and Neurohormones ; 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels ; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems ; 13. Neuromodulation: Mechanisms of Induced Changes in the Electrical Behavior of Nerve Cells ; 14. Sensory Receptors ; IV. BEHAVIOR AND PLASTICITY ; 15. The Birth and Death of a Neuron ; 16. Neuronal Growth and Trophic Factors ; 17. Adhesion Molecules and Axon Pathfinding ; 18. Formation, Maintenance, and Plasticity ; 19. Neural Networks and Behavior ; 20. Learning and Memory
