Full Description
Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.
Contents
Part I. Introductory material
1: Introduction
2: Drug administration and drug effectiveness
Part II. Fundamentals
3: Diffusion and drug dispersion
4: Diffusion in biological systems
5: Drug permeation through biological barriers
6: Drug transport by fluid motion
7: Pharmacokinetics of drug distribution
Part III. Drug delivery systems
8: Drug modification
9: Controlled drug delivery systems
10: Case studies in drug delivery
11: Postscript
Appendix A. Overview of polymeric biomaterials
A1. Nondegradable polymers
A2. Biodegradable polymers
A3. Water-soluble polymers
Appendix B. Useful data and nomenclature
B1. Physiological parameters
B2. Cardiovascular system
B3. Clinical chemistry
B4. Permeation and diffusion
B5. Protein properties
B6. Mathematical tables and functions
B7. Nomenclature
Index
