基本説明
薬理学の基礎原理を解説し、なぜ薬が治療効果を持つのかというユニークな視点を提示する。
A ready-reference pharmacopoeia of over 300 commonly used drugs. Now uses INNs (International Non-proprietray Names) throughout in line with 1998 European directives.
Full Description
Completely updated, the new edition of the Oxford Textbook of Clinical Pharmacology and Drug Therapy continues to provide medical students and clinicians with a unique insight into why drugs have their therapeutic effects, by presenting the basic pharmacological principles of pharmacology as they affect the patient. An understanding of these clinical pharmacological principles is essential for rational, safe, effective, and economical prescribing. The text shows how knowledge of the scientific basis of drug action is applied in a clinical context to devise the most effective treatments for disease and to maximize the therapeutic effects of the drugs being used. This new edition includes an appraisal of the value of evidence-based medicine and a greater discussion of issues in genetics. There are specialist contributors for areas of infectious disease, gastrointestinal disorders, blood disorders, general anaesthesia, cancer chemotherapy, and immunosuppression. The revision also includes updates to both the pharmacopoeia and the drug therapy section to reflect new developments in both available drugs and in their use.
Contents
SECTION 1; 1. The four processes of drug therapy; 1.2 The pharmacokinetic process; 2. The pharmaceutical process: Is the drug getting into the patient?; 2.2 Systematic availability (bioavailability); 2.3 Special drug formulations; 3. The pharmacokinetic process: Is the drug getting to its site of action?; 3.2 Drug distribution; 3.3 Drug metabolism; 3.4 Drug excretion; 3.5 Simple pharmacokinetic calculations; 3.6 The mathematics of pharmacokinetics; 4. The pharmacodynamic process: Is the drug producing the required pharmacological effect?; 4.2 Stereoisomerism and drug action; 4.3 Graded responses to drugs: the dose-response curve in drug therapy; 5. The therapeutic process: Is the pharmacological effect being translated into therapeutic effect?; 5.2 Translation of the pharmacological effect of a drug into a therapeutic effect during long-term drug therapy; 5.3 The aims of drug therapy; 6. Practical applications of the analysis of drug therapy; 6.2 The application of the processes of drug therapy in analysing failure to respond to treatment; 7. Monitoring drug therapy; 7.2 Monitoring the pharmacodynamic effects of drugs; 7.3 Monitoring drug pharmacokinetics (plasma concentration measurement); 8. Pharmacogenetics and pharmacogenomics; 8.2 Pharmacodynamic genetic variations; 9. Adverse reactions to drugs; 9.2 Incidence of adverse drug reactions; 9.3 Classification of adverse drug reactions; 9.4 Dose-related adverse drug reactions; 9.5 Non-dose-related adverse drug reactions; 9.6 Long-term and withdrawal effects causing adverse drug reactions; 9.7 Delayed effects causing adverse drug reactions; 9.8 Surveillance methods used in detecting adverse drug reactions; 10. Drug interactions; 10.2 Drugs likely to be involved in interactions; 10.3 Pharmaceutical interactions; 10.4 Pharmacokinetic interactions; 10.5 Pharmacodynamic interactions; 10.6 Lists clinically important drug interactions; 11. Drug therapy in young and in old people; 11.2 Drug therapy in old people; 12. Drug therapy and reproduction; 12.2 Hormone replacement therapy; 12.3 The treatment of infertility; 12.4 Drug therapy during pregnancy; 12.5 Drug therapy in the termination of pregnancy and in the management of preterm labour and labour; 12.6 Drug therapy and breast-feeding; 13. Patient compliance; 13.2 Methods of measuring compliance; 13.3 Methods of improving compliance; 14. Placebos; 14.2 Factors that influence the response to placebos; 14.3 Mode of action of placebos; 14.4 Adverse effects of placebos; 15. Drug discovery and development: the pharmaceutical industry and the regulatory authorities; 15.2 Drug development; 15.3 Post-marketing surveillance; 15.4 Advertising; 15.5 Regulatory authorities; 15.6 Local drug and therapeutics committees; 15.7 Drug costs; 16. Clinical trials; 16.2 The conduct of a clinical trial; 16.3 Ethics; 17. The drug history and the clinical examination and investigation of drug effects; 17.1 Taking the drug history; 17.2 Clinical examination and investigation of drug effects; 17.3 The importance of good records and communication; SECTION 2; 18. Principles of prescribing; 18.2 Evidence - based medicine; 18.3 How to choose a drug; 19. How to write a prescription; 19.2 Propriety names versus approved names; 19.3 Prescribing controlled drugs; 19.4 Repeat prescribing; 19.5 Abbreviations; 20. Sources of information on drugs; 20.2 Pharmacokinetics; 20.3 Pharmacological effects of drugs; 20.4 Therapeutics; 20.5 Pharmacogenetics; 20.6 Adverse effects of drugs; 20.7 Drug interactions; 20.8 Clinical trials; 20.9 Patient compliance; 20.10 Prescribing information; 20.11 Computerised databases; 20.12 Drug information services; 20.13 Bibliography; SECTION 3; 21. Introduction to drug therapy; 22.2 Chemotherapy of viral infections
