Full Description
This book was awarded the 2002 Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American. "Publishers Platelets" is a comprehensive new textbook of 61 chapters and 1,100 pages (approx.) written by over 100 world leaders in the field. "Platelets" is a single definitive source of state-of-the-art knowledge about platelets. There has been no textbook that specifically and fully covers the entire field of platelet biology and clinical medicine. "Platelets" now fills this need. "Platelets" encompasses: platelet biology; platelet function testing; the role of platelets in disease; inherited and acquired disorders of platelet number and function; pharmacology of antiplatelet agents; pharmacology of agents to increase platelet numbers and/or function; platelet transfusion medicine; and gene therapy. The intended audience for "Platelets" includes haematologists, cardiologists, stroke physicians, blood bankers, pathologists, and researchers in thrombosis and haemostasis as well as students and fellows in these fields.
This is a single comprehensive source of state-of-the-art knowledge about platelets with over 100 contributing authors from 13 countries. The authors of each chapter are world leaders in their fields. It is the definitive resource with 61 chapters, 1,100 pages (approx.), 12,000 references (approx.), 70 full color figures, 140 black and white figures, and 95 tables.
Contents
Foreword: A Brief and Highly Selective History of Ideas About Platelets in Health and Disease. Barry S. Coller Part One: Biology The Evolution of Mammalian Platelets. Megakaryocyte Development and Platelet Formation. Platelet Structure. Platelet Turnover and Aging. Platelet Receptors. The GPIb-IX-V Complex. Integrin aIIbb3. Thrombin Receptors. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium. Platelet Polymorphisms. Platelet Secretion. Signal Transduction During the Initiation, Extension, and Perpetuation of Platelet Plug Formation. Platelet Thrombus Formation in Flowing Blood. Interactions Between Platelets and the Coagulation System. Platelet-Derived Microparticles. Platelet Function in the Newborn. Part Two: Tests of Platelet Function Platelet Count. The Bleeding Time. Platelet Aggregation. Flow Cytometry. Ultegra Rapid Platelet Function Analyzer. Platelet Function Analyzer (PFA)-100. Cone and Plate(let) Analyzer. Perfusion Chambers. Animal Models. Part Three: The Role of Platelets in Disease Atherosclerosis and Coronary Artery Disease. Ischemic Cerebrovascular Disease. Peripheral Vascular Disease. Diabetes Mellitus. Renal Disease. Inflammation. Antimicrobial Host Defense. Tumor Growth and Metastasis. Alzheimer Disease. Psychiatric Disorders. Part Four: Disorders of Platelet Number and Function The Clinical Approach to Disorders of Platelet Number and Function. Immune Thrombocytopenic Purpura. HIV-1-related Thrombocytopenia. Heparin-induced Thrombocytopenia. Drug-induced Thrombocytopenia. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndrome. Thrombocytopenia in Pregnancy. Thrombocytopenia in the Newborn. Pseudothrombocytopenia. Thrombocytosis and Essential Thrombocythemia. Inherited Disorders of Platelet Function. Acquired Disorders of Platelet Function. Cardiopulmonary Bypass. Part Five: Pharmacology: Antiplatelet Therapy Aspirin. GPIIb-IIIa Antagonists. Clopidogrel and Ticlopidine. Dipyridamole. Cilostazol. Part Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function Thrombopoietin. Interleukin 11. Desmopressin. Factor VIIa. Part Seven: Transfusion Medicine Platelet Storage and Transfusion. Platelet Transfusion in Infants and Children. Platelet Substitutes and Novel Methods of Platelet Preservation. Part Eight: Gene Therapy Gene Therapy for Platelet Disorders.
