Nitric Oxide : Biology and Pathobiology (1ST)

Nitric Oxide : Biology and Pathobiology (1ST)

  • ただいまウェブストアではご注文を受け付けておりません。 ⇒古書を探す
  • 製本 Hardcover:ハードカバー版/ページ数 1003 p.
  • 言語 ENG
  • 商品コード 9780123704207
  • DDC分類 572.54

Full Description


Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems.NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells.NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis.This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications.

Contents

ContributorsPreface Section I Overview of Basic PrinciplesChapter 1 Introduction and OverviewSection II Principles of BiologyA. Chemical BiologyChapter 2 The Chemical Properties of Nitric Oxide and Related Nitrogen OxidesChapter 3 The Chemical Biology of Nitric OxideChapter 4 The Biological Chemistry of PeroxynitriteChapter 5 A Comparison of the Biological Reactivity of Nitric Oxide and PeroxynitriteB. Nitric Oxide SynthasesChapter 6 Structural Variations to Accommodate Functional Themes of the Isoforms of NO SynthasesChapter 7 Regulation of the Expression of Nitric Oxide Synthase IsoformsChapter 8 Molecular Regulation of Inducible Nitric Oxide SynthaseChapter 9 Molecular Control of Endothelial Derived Nitric Oxide: A New Paradigm for Endothelial NOS Regulation by Posttranslational ModificationC. Regulation of Nitric Oxide ProductionChapter 10 Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive RoleChapter 11 Regulation of Arginine Availability and Its Impact on NO SynthesisChapter 12 Relationship between Arginase Activity and Nitric Oxide ProductionD. Transport, Membrane Interactions, and Oxygen TransportChapter 13 The Physical Properties of Nitric Oxide: Determinants of the Dynamics of NO in TissueChapter 14 Membrane Transport of Arginine and Cationic Amino Acid AnalogsChapter 15 The Respiratory Cycle: A Three-Gas SystemE. Nitric Oxide and Oxidative StressChapter 16 Role for Nitric Oxide and Other Radicals in Signal TransductionChapter 17 Antioxidant Actions of Nitric OxideChapter 18 Mechanisms through Which Reactive Nitrogen and Oxygen Species Interact with Physiological Signaling SystemsChapter 19 Nitric Oxide, Oxygen Radicals, and Iron MetabolismChapter 20 Redox Modulation of Iron Regulatory Proteins by Nitric Oxide and PeroxynitriteChapter 21 Nitric Oxide, Oxidative Stress, and Signal TransductionChapter 22 Mechanisms of Antioxidant Defense against Nitric Oxide/PeroxynitriteChapter 23 Regulation of Oxygen Metabolism by Nitric OxideF. Signal Transduction MechanismsChapter 24 Structure-Function Relationships in NO-Sensitive Guanylyl CyclaseChapter 25 Mechanism of Activation of Soluble Guanylyl Cyclase by NO: Allosteric Regulation through Changes in Heme Coordination GeometryChapter 26 Cyclic GMP-Mediated Signaling Mechanisms in Smooth MuscleSection III Principles of PathobiologyA. NO and the Nervous SystemChapter 27 Influence of Nitric Oxide on Neuroendocrine Function and BehaviorChapter 28 Nitric Oxide and Cerebral IschemiaChapter 29 Role of Nitric Oxide in Neuronal Protection versus ApoptosisChapter 30 Nitric Oxide and Autoimmune Disease in the Nervous System: Pathobiology of Inflammation and DemyelinationB. NO and Cardiovascular FunctionChapter 31 Role of Nitric Oxide in the Regulation of Blood FlowChapter 32 Nitric Oxide Synthase Gene TransferChapter 33 Functional Influence of Gene Transfer of Recombinant Nitric Oxide Synthase to Cardiovascular SystemChapter 34 Nitric Oxide and Vascular Endothelial DysfunctionChapter 35 Endothelium-Derived Hyperpolarizing Factor and Its Interaction with NOChapter 36 Role of Nitric Oxide in Myocardial FunctionChapter 37 Role of Nitric Oxide in the MicrocirculationChapter 38 Activation of NOS by Ca2+-Dependent and Ca2+-Independent MechanismsC. Pathophysiological Mechanisms of Nitric OxideChapter 39 Role of Nitric Oxide in Ischemia-Reperfusion InjuryChapter 40 Nitric Oxide: A Critical Determinant in Ischemia-ReperfusionChapter 41 Role of Nitric Oxide in Myocardial Ischemia-Reperfusion InjuryChapter 42 Use of Mutant Mice to Elucidate Neuroprotective and Neurotoxic Actions of Nitric Oxide in Cerebral IschemiaChapter 43 Neurotoxic Actions and Mechanisms of Nitric OxideChapter 44 Role of Macrophage-Derived Nitric Oxide in Target Cell InjuryChapter 45 Physiological and Pathophysiological Roles of Nitric Oxide in Gastrointestinal FunctionChapter 46 Pathophysiological Effects of High-Output Production of Nitric OxideChapter 47 Nitric Oxide and Septic ShockChapter 48 Nitric Oxide and Vascular DiseaseChapter 49 Cytotoxic Role of Nitric Oxide in DiabetesChapter 50 Role of Inducible Nitric Oxide Synthase in Autoimmune or Other Immune-Mediated DiseasesChapter 51 Nitric Oxide and Platelet FunctionChapter 52 Pathophysiological Roles of Nitric Oxide in InflammationChapter 53 Nitric Oxide, Chronic Joint Inflammation, and PainChapter 54 Nitric Oxide and CancerD. Clinical Significance of Nitric OxideChapter 55 Vascular Nitric Oxide in Health and DiseaseChapter 56 Clinical Therapy with Inhaled Nitric Oxide in Respiratory DiseasesChapter 57 Airborne Nitric Oxide in Health and DiseaseChapter 58 Nitric Oxide and Persistent Pulmonary Hypertension in the NewbornIndex