基本説明
Covers the ever-widening sphere of current cancer knowledge and clinical practice. 7th ed.:2003.
Full Description
The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practice. In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging and therapy. The book is a testament to the editorial panel's creed that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. Cancer Medicine 8 does a superb job of bringing scientific principles into clinical practice. This text is the ultimate resource of new information providing the basis for better informed cancer therapy choices.Cancer Medicine 8 features hundreds of 4-color illustrations, photographs, tables, graphs and algorithms that make this text an invaluable clinical tool in recognizing characteristic appearances of both patient and tissue.The 137 tightly focused chapters are organized into 5 sections:I: Cardinal Manifestations of CancerII: Scientific Foundations of CancerIII: Principles of Cancer DiagnosisIV: Principles of Therapeutic ModalitiesV: Principles of Multidisciplinary ManagementMajor Revisions:Chapter 6: Oncogenes An entire section is devoted to oncogenes like kit, Ret, Braf, Akt genes and the new drugs that specifically target them. This chapter not only provides a list of these new therapies but also insight as to how they target the oncogenes and their mutations, as well as therapy response and efficacy.Chapter 11: Tumor Angiogenesis This chapter provides a wealth of new data and understanding of the mechanisms of angiogenesis and how it contributes to the malignancy of various cancers The Clinical Advancement section provides an extensive summary of new trials investigating numerous novel angiogenesis agents Chapter 33: Chemoprevention This chapter also provides a considerable amount of new information for a broad range of clinical trials such as the HPV vaccine trial Future, Select, Star, Approve and PreSAP. The rationales for these trials are discussed and resulting data from the completed trials are presented. Chapter 55: Cytokines Research on cytokines is another area that is exploding in magnitude. This chapter presents a wealth of new information on promising new therapeutic agents.There is also updated information on the therapeutic usage of currently available agents such as hemotopoietic growth factors (HGF), erythropoietin and thromobopoietic agents. Chapter 56: Monoclonal Serotherapy A considerable amount of research has been done in the past few years on therapeutic and targeted agents in cancer therapy. Updated information and data is provided from recent trials for therapies previously discussed in Cancer Medicine edition 7 covering therapeutic agents and targeted toxins.Chapter 77: Neoplasms of the Head and Neck There is a discussion of changes in treatment methods for certain cancers such as the recent shift from surgery to combined chemotherapy with radiotherapy for tonsillar cancer, nasal and paranasal sinuses cancers and laryngeal cancer. Chapter 78: Lung Cancer Advances in diagnostic techniques are described such as ultrasound-guided fine needle aspiration or electromagnetic navigation diagnostic bronchoscopy. Video assisted thoracoscopic surgery (VATS) discussion is updated. New sections are devoted to prognostic and predictive biomarkers.
Contents
PART ICancer James F. Holland, Emil Frei, III, Waun Ki Hong, Donald Kufe, Robert Bast, William Hait, Raphael Pollock, Ralph WeichselbaumSECTION 1: CANCER BIOLOGY2: Molecular Biology, Genomics, and Proteomic, and Mouse Models of Human Cancer Kornelia Polyak, Matthew Meyerson, William Hahn, David Tuveson3: Cell Proliferation and Differentiation Michael Andreeff, David W. Goodrich, H. Phillip Koeffler4: Apoptosis and Cancer John Reed5: Growth Factors and Signal Transduction in Cancer Stuart A. Aaronson, Luca Grumolato6: Oncogenes Marco A. Pierotti, Milo Frattini, Gabriella Sozzi, Carlo M. Croce7: Tumor Supressor Genes Gen-Ho Park, Bert Vogelstein, David Cosgrove 8: Genomic Alterations and Chromosomal Abberations in Human Cancer Jeff Trent, Kevin M. Brown, Jonathan J. Keats, Aleksandar Sekulic, Cheryl L. Willman9: Biochemistry of Cancer Raymond W. Ruddon, Donald W. Kufe10: Invasion and Metastases Elise C. Kohn11: Tumor Angiogenesis John Heymach, Judah Folkman, Raghu Kalluri12: Epigenetics (to include Novel Treatment) Steve BaylinSECTION 2: CANCER IMMUNOLOGY13: Cancer Immunotherapy Karl S Peggs, Sergio A Quezada, Padmanee Sharma, James P AllisonSECTION 3: CANCER ETIOLOGY14: Genetic Predisposition to Cancer Henry T. Lynch, Vadana Gupta, Marcia S. Brose15: Chemical Carcinogenesis Ainsley Weston, Curtis C. Harris16: Hormones and the Etiology of CancerLeslie Bernstein, C. Leigh Pearce, Iona Cheng, Katherine DeLellis Henderson17: Ionizing Radiation David J. Grdina18: Ultraviolet Radiation CarcinogenesisJames E. Cleaver, David L. Mitchell19: Inflammation, Trauma and Physical Agents in Cancer Debbie Laskin20: RNA Tumor Viruses, Robert Gallo, Marvin S. Reitz21: Herpesviruses Jeffrey I. Cohen22: Papillomaviruses and Cervical Neoplasia Christopher P. Crum, Catherine McLachlin23: Hepatitis Viruses Max W. Sung, Swan N. Thung24: Parasites Piero MustacchiSECTION 4: TRANSLATIONAL CANCER MEDICINE25: Molecular Imaging Juri Gerlovani 26: Molecular Diagnostics in Cancer Bryan T. Hennessy, Robert C. Bast, Jr., Gordon B. Mills27: Personalized Medicine in Oncology Drug Development William N. Hait, Nicolas Dracopoli, Steve Heller, Chris H. Takimoto28: Genomic and Systems Biology Joseph W. Gray29: Cancer Nanotechnology Mauro FerrariSECTION 5: CANCER EPIDEMIOLOGY, PREVENTION and SCREENING30: Cancer Epidemiology Michael J. Thun 31: Prevention of Tobacco-Related Products Steve Hecht, Dorothy Hatsukami32: Nutrition in the Etiology and Prevention of Cancer Steven K. Clinton 33: Chemoprevention of Cancer Scott M. Lippman, Waun Ki Hong34: Cancer Screening and Early Detection Robert A. Smith, Stephen W. Duffy, Otis W. BrawleySECTION 6: CLINICAL TRIALS AND OUTCOMES ASSESSMENT35: Statistical Innovations in Cancer Research Don Berry36: Outcomes Assessment James A. TalcottSECTION 7: CANCER PATHOLOGY37: Principles of Cancer Pathology Stan HamiltonSECTION 8: IMAGING38: Principles of Imaging Edward F. Patz, Jr. 39: Interventional Radiology for the Cancer Patient Michael Wallace, Rony AvritscherSECTION 9: SURGICAL ONCOLOGY40: Principles of Surgical Oncology Raphael E. Pollock, Michael A. Choti, Donald L. MortonSECTION 10: RADIATION ONCOLOGY41: Principles of Radiation Oncology Joseph K. Salama, Mark W. Dewhirst, Ralph R. WeichselbaumSECTION 11: MEDICAL ONCOLOGY42: Principles of Medical Oncology William N. Hait, MD, ,PhD James F. Holland, MD, ScD (hc) Emil Frei III, MD Donald W. Kufe, MD Robert C. Bast Jr, MD Waun Ki Hong, MDSECTION 12: CHEMOTHERAPY43: Cytokinetics Larry Norton, Theresa Ann Gilewski44: Principles of Dose, Schedule, and Combination Chemotherapy Joseph P. Eder, William Hait45: Preclinical and Early Clinical Development of New Anticancer Agents Daniel D. Von Hoff, Axel Hanuske46: Pharmacology William Plunkett, Mark Ratain 47: Drug Resistance and Its Clinical Circumvention Jeffrey Moscow, Erasmus Schneider, Branimir I. Sikic, Charles S. Morrow, Kenneth H. CowanSECTION 13: CHEMOTHERAPEUTIC AGENTS48: Folate Antagonists Joseph R. Bertino, Barton A. Kamen, Peter D. Cole49: Pyrimidine and Purine Antimetabolites Giuseppe Pizzorno, Sunil Sharma, Yung-Chi Cheng50: Alkylating Agents and Platinum Antitumor Compounds Michael Colvin51: Drugs that Target DNA Topoisomerases William N. Hait, Eric H. Rubin52: Microtubule-Targeting Natural Products Eric Rowinsky SECTION 14: BIOTHERAPEUTICS53: InterferonsErnest C. Borden 54: Cytokines and Hematopoietic Growth FactorsSuhendan Ekmekcioglu, Razelle Kurzrock, Elizabeth A. Grimm55: Monoclonal Serotherapy Robert C. Bast, Michael R. Zalutskym, Arthur E. Frankel, Robert J. Kreitman56: Vaccines and Immunostimulants Jeff Schlom, James L. Gulley, Philip M. Arlen, James W. Hodge SECTION 15: ENDOCRINE THERAPY57: Estrogens, Antiestrogens and Aromatase Inhibitors Aman U. Buzdar, Shaheenah Dawood, Harold A. Harvey, V. Craig Jordan 58: Androgen Deprivation Strategies In The Treatment Of Advanced Prostate Cancer Samuel R. Denmeade SECTION 16: GENE THERAPY59: Cancer Gene Therapy Sunil J. Advani, Ralph R. Weichselbaum, Donald W. KufeSECTION 17: BONE MARROW TRANSPLANTATION60: Hematopoietic Cell Transplantation Roy Jones, Elizabeth Shpall, Richard Champlin SECTION 18: PSYCHO-ONCOLOGY61: Principles of Psycho-Oncology Jimmie C. Holland SECTION 19: CANCER REHABILITATION MEDICINE62: Principles of Cancer Rehabilitation Medicine Kristjan T. Ragnarsson SECTION 20: MULTIDISCIPLINARY MANAGEMENT63: Multidisciplinary Management James F. Holland, Emil Frei III, III, Waun Ki Hong, Donald W. Kufe, Robert C. Bast Jr, Raphael E. Pollock, Ralph R. Weichselbaum, William N. Hait64: Pregnancy and Cancer Jennifer K. Litton 65: Cancer and Aging Arti Hurria, Hyman B. Muss, Harvey J. Cohen66: The Role of Integrative Oncology in Cancer Care Lorenzo Cohen, Nancy Russell, Kay Garcia, Moshe FrenkelSECTION 21: PAIN AND PALLIATION67: Palliative Care Diane Meier, Cardinale B. Smith, Gabrielle R. Goldberg68: Management of Cancer Pain Natalie Moryl, Alan CarverSECTION 22: CENTRAL NERVOUS SYSTEM69: Primary Neoplasms of the Central Nervous System in Adults Lisa M. DeAngelis70: Brain Metastases Lisa M. DeAngelisSECTION 23: THE EYE71: Neoplasms of the Eye Amy C. Schefler, David H. Abramsom, Ira J. Dunkel, Beryl McCormickSECTION 24: ENDOCRINE GLANDS72: Neoplasms of the Endocrine Glands: Pituitary Neoplasms Kalman D. Post 73: Neoplasms of the Thyroid Steven I. Sherman 74: Neoplasms of the Adrenal Cortex David E. Schteingart75: Neuroendocrine System and Gastroentero-pancreatic Endocrine System Evan VosburghSECTION 25: HEAD AND NECK76: Neoplasms of the Head and Neck Michael E. Kupferman, Erich M. Sturgis, David L. Schwartz, Adam Garden, Merrill S. KiesSECTION 26: THE THORAX77: Cancer of the Lung Charles Lu, Amir Onn, Ara A. Vaporciyan, Joe Y. Chang, Bonnie S. Glisson, Ritsuko Komaki, Ignacio I. Wistuba, Jack A. Roth, Roy S. Herbst78: Malignant Mesothelioma Harvey I. Pass, Michele Carbone, Hedy Kindler79: Thymomas and Thymic Tumors A. Philippe Chahinian80: Tumors of the Heart and Great Vessels Sarina van der Zee, A. Philippe Chahinian, Valentin Fuster81: Primary Germ Cell Tumors of the Thorax Anthony F. Greco, John D. HainsworthSECTION 27: GASTROINTESTINAL TRACT82: Neoplasms of the Esophagus Stephen G. Swisher, David C. Rice, Jaffer A. Ajani, Ritsuko K. Komaki, Mark K. Ferguson83: Carcinoma of the Stomach Paul Mansfield, James Yao, Christopher Crane, Takeshi Sano84A: Treatment of Liver Metastases Nancy E. Kemeny, Micheal D'Angelica84B: Kemeny Treatment of Liver Metastases Max W. Sung, Swan N. Thung85: Gallbladder and Bile Duct Cancer Ahmed O. Kaseb, Steven A. Curley, Melanie Thomas 86: Neoplasms of the Exocrine Pancreas Robert A. Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans87: Neoplasms of the Small Intestine, Vermiform Appendix, Peritoneum and Carcinoma of the Colon and Rectum James C. Padussis, Georgia M. Beasley, Nicole McMahon, Douglas S. Tyler, Kirk Ludwig88: Neoplasms of the Anus Bruce MinskySECTION 28: GENITOURINARY TRACT89: Renal Cell Carcinoma Derek Raghavan, Brian I. Rini, Daniel Y.C. Heng, Ming Zhou, Andrew Novick90: Tumors Of The Renal Pelvis And Ureter Derek Raghavan, Ali-Reza Golshayan, Inderbir Gill, Cristina Magi-Galluzzi91: Bladder Cancer Derek Raghavan,John Stein, Richard Cote, J. Stephen Jones92: Neoplasms of the Prostate Christopher Logothetis93: Tumors of the Penis and Urethra Donald F. Lynch94: Testis Cancer Christian Kollmansberger, Siamak Daneshmand, Eric Hansen, Christopher L. Corless, Bruce J. Roth, Craig R. NicholsSECTION 29: FEMALE REPRODUCTIVE ORGANS95: Neoplasms of the Vulva and Vagina Jacob Rotmensch 96: Neoplasms of the Cervix Anuja Jhingran97: Endometrial Cancer Carmel J. Cohen, Jamal Rahaman98: Neoplasms of the Fallopian Tube Carmel J. Cohen, Jamal Rahaman99: Ovarian Cancer Jonathan S. Berek, Robert Bast, Michael L. Friedlander100: Molar Pregnancy and Gestational Trophoblastic Neoplasia Ross S. Berkowitz, Donald Goldstein101: Gynecologic Sarcomas Carmel J. Cohen, Jamal RahamanSECTION 30: THE BREAST102: Neoplasms of the Breast Gabriel N. Hortobagyi, Laura Esserman, Thomas A. BuchholzSECTION 31: THE SKIN103: Melanoma Patrick Hwu, Jeff Gershenwald, Boris Bastian104: Other Skin Cancers Arthur Sober, Victor A. NeelSECTION 32: BONE AND SOFT TISSUE105: Bone Tumors Tim Damron106: Soft Tissue Sarcomas Peter Pisters , Brian O'Sullivan, Robert G. MakiSECTION 33: HEMATOPOIETIC SYSTEM107: The Myelodyplastic Syndrome Lewis R. Silverman108: Acute Myeloid Leukemia and Other Mast Cell Neoplasms Charles A. Schiffer, Richard M. Stone 109: Chronic Myeloid Leukemia Magop M. Kantarjian, Jorge Cortes110: Acute Lymphocytic Leukemia Stefan Faderl, Ching-Hon Pui, Susan O'Brien, Hagop M. Kantarjian111: Chronic Lymphocytic Leukemia Kanti Rai, Matthew Kaufman112: Hodgkin Disease James O'Armitage, Peter M. Mauch, Lawrence Weiss113: Non-Hodgkin Lymphoma Arnold S. Freedman114: Mycosis Fungoides and the Sezary Syndrome Richard T. Hoppe, Youn H. Kim, Ranjana Advani115: Plasma Cell Tumors Kenneth C. Anderson, Teru Hideshima, Noopur Raje116: Myeloproliferative Neoplasms: Essential Thrombocythemia, Primary Myelofibrosis and Polycythemia Vera Ayalew Tefferi 117: Neoplasms in Acquired Immunodeficiency Syndrome David T. Scadden, Jeremy S. AbramsonSECTION 35: UNKNOWN PRIMARY SITE118: Neoplasms of Unknown Primary Site John D. Hainsworth, F. Anthony GrecoSECTION 36: PEDIATRIC ONCOLOGY119: Principles of Pediatric Oncology Maura O'Leary, Greg Reaman 120: Cancer Anorexia and Cachexia Takao Ohnuma121: Antiemetic Therapy David Ettinger, Aditya Bardia122: Neurologic Complications Lisa M. DeAngelis123: Dermatologic Complications of Cancer Chemotherapy Cindy Berthelot, Joy H. Kunishige, Narin Apisarnthanarax, Madeleine M. Duvic124: Skeletal Complications Samuel Kenan, Jeff Mechanick, Michael Via 125: Hematologic Complications and Blood Bank Support Kenneth C. Anderson, Richard M. Kaufman 126: Coagulopathic Complications of Cancer Patients Jacob H. Rand, Maria DeSancho127: Urologic Complications Christopher J. Logothetis, Diana M. Hey 128: Cardiac Complications Michael S. Ewer, Steven M. Ewer, Thomas Suter 129: Respiratory Complications Vickie R. Shannon, George A. Eapen, Carlos A. Jimenez, Rodolfo C. Morice, Elizabeth L. Travis, Lara Bashoura, Amar Safdar, Scott E. Evans, Roberto Adachi, Saadia A. Faiz, Diwakar D. Balachandran, Joseph L. Nates, S. Egbert Pravinkumar, Burton F. Dickey130: Gastrointestinal and Hepatic Complications in Cancer Patients Robert Bresalier, Marta L. Davila131: Oral Complications of Cancer and Their Treatment Stephen T. Sonis132: Gonadal Complications Catherine E. Klein, Peter Kabos133: Endocrine Complications and Paraneoplastic Syndromes Robert F. Gagel, Sai-Ching, Jim Yeung134: Treatment -Related Secondary Cancers Susan R. Rheingold, Alfred I. Neugut, Thomas Uldrick, Anna T. Meadows135: Infections in Patients with Cancer Kenneth V.I. Rolston, Gerald P. BodeySECTION 39: ONCOLOGIC EMERGENCIES136: Oncologic Emergencies S. Jim Yeung, Carmen EscalanteSECTION 40: ONCOLOGY AND INFORMATICS137: Oncology Informatics Edward P. Ambinder
