Full Description
This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results.
Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.
Contents
Cancer Epigenetics: An Introduction.- Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program.- Epigenome-Wide Association Studies (EWAS): Past, Present, and Future.- Epigenetic Biomarkers in Liver Cancer.- Cancer Type Specific Epigenetic Changes: Gastric Cancer.- Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer.- Prostate Cancer Epigenome.- CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer.- Analysis of DNA Methylation in Pancreatic Cancer: An Update.- Epigenetics of Urothelial Carcinoma.- Epigenetics of Prostate Cancer.- Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options.- Techniques to Access Histone Modifications and Variants in Cancer.- Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS.- Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer.- Histone Modifications Associated with Cancer Cell Migration and Invasion.- Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers.- Cancer-Associated Infectious Agents and Epigenetic Regulation.- Toxicoepigenomics and Cancer: Implications for Screening.- Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome.- Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies.- Epigenetics of Colorectal Cancer.- Epigenetics in Breast and Prostate Cancer.- Epigenetic Inhibitors.- Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies.- Epigenetic Approaches in Glioblastoma Multiforme and Their Implication in Screening and Diagnosis.- Detection of Circulatory MicroRNAs in Prostate Cancer.- Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases.- Epigenetic Regulation in Biopsychosocial Pathways.- Viral Epigenetics.- P53 Tumor Suppression Network in Cancer Epigenetics.- Promoter Hypermethylation as a Biomarker in Prostate Adenocarcinoma.- Sequencing the Cancer Methylome.- Global DNA Methylation Profiling Technologies and the Ovarian Cancer Methylome.- Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer.- At the Crossroad Between Obesity and Gastric Cancer.- Detection of Epigenetic Aberrations in the Development of Hepatocellular Carcinoma.- Specific Type Epigenetic Changes in Cervical Cancers.- Epigenetics in Head and Neck Cancer.- Epigenetic Therapy for Colorectal Cancer.
