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MASTER MODERN MEDICINE!Introducing the Landmark Twentieth Edition of the Global Icon of Internal MedicineThe definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithmsRecognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.Essential for practice and education, the landmark 20th Edition features:Thoroughly revised content-covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison's. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.State-of-the-art coverage of disease mechanisms: Harrison's focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison's summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system's role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine- Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.Important and timely new chapters-such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more-offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.End-of-chapter suggested readings reinforc
Contents
CONTRIBUTORSPREFACEPart 1: The Profession of Medicine1 The Practice of MedicineThe Editors2 Promoting Good HealthDonald M. Lloyd-Jones, Kathleen M. McKibbin3 Decision-Making in Clinical MedicineDaniel B. Mark, John B. Wong4 Screening and Prevention of DiseaseKatrina A. Armstrong, Gary J. Martin5 Health Care Systems in Developed CountriesRichard B. Saltman6 The Safety and Quality of Health CareDavid W. Bates7 Racial and Ethnic Disparities in Health CareJoseph R. Betancourt, Alexander R. Green8 Ethical Issues in Clinical MedicineBernard Lo, Christine Grady9 Palliative and End-of-Life CareEzekiel J. EmanuelPart 2: Cardinal Manifestations and Presentation of DiseasesSection 1: Pain10 Pain: Pathophysiology and ManagementJames P. Rathmell, Howard L. Fields11 Chest DiscomfortDavid A. Morrow12 Abdominal PainDanny O. Jacobs13 HeadachePeter J. Goadsby14 Back and Neck PainJohn W. EngstromSection 2: Alterations in Body Temperature15 FeverCharles A. Dinarello, Reuven Porat16 Fever and RashElaine T. Kaye, Kenneth M. Kaye17 Fever of Unknown OriginChantal P. Bleeker-Rovers, Jos W. M. van der MeerSection 3: Nervous System Dysfunction18 SyncopeRoy Freeman19 Dizziness and VertigoMark F. Walker, Robert B. Daroff20 FatigueJeffrey M. Gelfand, Vanja C. Douglas21 Neurologic Causes of Weakness and ParalysisMichael J. Aminoff22 Numbness, Tingling, and Sensory LossMichael J. Aminoff23 Gait Disorders, Imbalance and FallsJessica M. Baker, Lewis R. Sudarsky24 Confusion and DeliriumS. Andrew Josephson, Bruce L. Miller25 DementiaWilliam W. Seeley, Bruce L. Miller26 Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes and Other Cerebral DisordersM.-Marsel Mesulam27 Sleep DisordersThomas E. Scammell, Clifford B. Saper, Charles A. CzeislerSection 4: Disorders of Eyes, Ears, Nose, and Throat28 Disorders of the EyeJonathan C. Horton29 Disorders of Smell and TasteRichard L. Doty, Steven M. Bromley30 Disorders of HearingAnil K. Lalwani31 Sore Throat, Earache, and Upper Respiratory SymptomsMichael A. Rubin, Larry C. Ford, Ralph Gonzales32 Oral Manifestations of DiseaseSamuel C. DursoSection 5: Alterations in Circulatory and Respiratory Functions33 DyspneaRebecca M. Baron34 Cough Christopher H. Fanta35 HemoptysisAnna K. Brady, Patricia A. Kritek36 Hypoxia and CyanosisJoseph Loscalzo37 EdemaEugene Braunwald, Joseph Loscalzo38 Approach to the Patient with a Heart MurmurPatrick T. O'Gara, Joseph Loscalzo39 PalpitationsJoseph LoscalzoSection 6: Alterations in Gastrointestinal Function40 DysphagiaIkuo Hirano, Peter J. Kahrilas41 Nausea, Vomiting, and IndigestionWilliam L. Hasler42 Diarrhea and ConstipationMichael Camilleri, Joseph A. Murray43 Unintentional Weight LossJ. Larry Jameson44 Gastrointestinal BleedingLoren Laine45 JaundiceSavio John, Daniel S. Pratt46 Abdominal Swelling and AscitesKathleen E. Corey, Lawrence S. FriedmanSection 7: Alterations in Renal and Urinary Tract Function47 Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain SyndromeJohn W. Warren48 Azotemia and Urinary AbnormalitiesDavid B. Mount49 Fluid and Electrolyte DisturbancesDavid B. Mount50 Hypercalcemia and HypocalcemiaSundeep Khosla51 Acidosis and AlkalosisThomas D. DuBose, Jr.Section 8: Alterations in the Skin52 Approach to the Patient with a Skin DisorderKim B. Yancey, Thomas J. Lawley53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin DisordersLeslie P. Lawley, Calvin O. McCall, Thomas J. Lawley54 Skin Manifestations of Internal DiseaseJean L. Bolognia, Irwin M. Braverman55 Immunologically Mediated Skin DiseasesKim B. Yancey, Thomas J. Lawley56 Cutaneous Drug ReactionsRobert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai57 Photosensitivity and Other Reactions to LightAlexander G. Marneros, David R. BickersSection 9: Hematologic Alterations58 Interpreting Peripheral Blood Smears Dan L. Longo59 Anemia and PolycythemiaJohn W. Adamson, Dan L. Longo60 Disorders of Granulocytes and MonocytesSteven M. Holland, John I. Gallin61 Bleeding and ThrombosisBarbara A. Konkle62 Enlargement of Lymph Nodes and SpleenDan L. LongoPart 3: Pharmacology63 Principles of Clinical PharmacologyDan M. Roden64 PharmacogenomicsDan M. RodenPart 4: Oncology and HematologySection 1: Neoplastic Disorders65 Approach to the Patient with CancerDan L. Longo66 Prevention and Early Detection of CancerJennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer67 Cancer GeneticsFred Bunz, Bert Vogelstein68 Cancer Cell BiologyJeffrey W. Clark, Dan L. Longo69 Principles of Cancer TreatmentEdward A. Sausville, Dan L. Longo70 Infections in Patients with CancerRobert W. Finberg71 Oncologic EmergenciesRasim Gucalp, Janice P. Dutcher72 Cancer of the SkinBrendan D. Curti, Sancy Leachman, Walter J. Urba 73 Head and Neck CancerEverett E. Vokes74 Neoplasms of the LungLeora Horn, Christine M. Lovly75 Breast CancerDaniel F. Hayes, Marc E. Lippman76 Upper Gastrointestinal Tract CancersRobert J. Mayer77 Lower Gastrointestinal CancersRobert J. Mayer78 Tumors of the Liver and Biliary TreeJosep M. Llovet79 Pancreatic CancerDaniel D. Von Hoff80 Neuroendocrine Tumors of the Gastrointestinal Tract and PancreasRobert T. Jensen81 Renal Cell CarcinomaRobert J. Motzer82 Cancer of the Bladder and Urinary TractNoah M. Hahn83 Benign and Malignant Diseases of the ProstateHoward I. Scher, James A. Eastham84 Testicular CancerDavid J. Vaughn85 Gynecologic MalignanciesDavid Spriggs86 Primary and Metastatic Tumors of the Nervous SystemLisa M. DeAngelis, Patrick Y. Wen87 Soft Tissue and Bone Sarcomas and Bone MetastasesShreyaskumar R. Patel88 Carcinoma of Unknown PrimaryGauri R. Varadhachary, James L. Abbruzzese89 Paraneoplastic Syndromes: Endocrinologic/HematologicJ. Larry Jameson, Dan L. Longo90 Paraneoplastic Neurologic Syndromes and Autoimmune EncephalitisJosep Dalmau, Myrna R. Rosenfeld91 Late Consequences of Cancer and Its TreatmentCarl E. Freter, Dan L. LongoSection 2: Hematopoietic Disorders92 Hematopoietic Stem CellsDavid T. Scadden, Dan L. Longo93 Iron Deficiency and Other Hypoproliferative AnemiasJohn W. Adamson94 Disorders of HemoglobinEdward J. Benz, Jr.95 Megaloblastic AnemiasA. Victor Hoffbrand96 Hemolytic Anemias Lucio Luzzatto97 Anemia Due to Acute Blood LossDan L. Longo98 Bone Marrow Failure Syndromes Including Aplastic Anemia and MyelodysplasiaNeal S. Young99 Polycythemia Vera and Other Myeloproliferative NeoplasmsJerry L. Spivak100 Acute Myeloid LeukemiaWilliam Blum, Clara D. Bloomfield101 Chronic Myeloid LeukemiaHagop Kantarjian, Jorge Cortes102 Acute Lymphoid LeukemiaDieter Hoelzer 103 Chronic Lymphocytic LeukemiaJennifer A. Woyach, John C. Byrd104 Non-Hodgkin's LymphomaCaron A. Jacobson, Dan L. Longo105 Hodgkin's Lymphoma Caron A. Jacobson, Dan L. Longo106 Less Common Hematologic MalignanciesAyalew Tefferi, Dan L. Longo107 Plasma Cell DisordersNikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson108 AmyloidosisJohn L. Berk, Vaishali Sanchorawala 109 Transfusion Biology and TherapyJeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson110 Hematopoietic Cell TransplantationFrederick R. AppelbaumSection 3: Disorders of Hemostasis111 Disorders of Platelets and Vessel WallBarbara A. Konkle112 Coagulation DisordersValder R. Arruda, Katherine A. High113 Arterial and Venous ThrombosisJane E. Freedman, Joseph Loscalzo114 Antiplatelet, Anticoagulant, and Fibrinolytic DrugsJeffrey I. WeitzPart 5: Infectious DiseasesSection 1: Basic Considerations in Infectious Diseases115 Approach to the Patient with an Infectious DiseaseNeeraj K. Surana, Dennis L. Kasper116 Molecular Mechanisms of Microbial PathogenesisGerald B. Pier117 Approach to the Acutely Ill Infected Febrile PatientTamar F. Barlam, Dennis L. Kasper118 Immunization Principles and Vaccine UseNancy Messonnier, Anne Schuchat, Lisa A. Jackson119 Health Recommendations for International TravelJay S. Keystone, Phyllis E. Kozarsky120 Climate Change and Infectious DiseaseAaron S. BernsteinSection 2: Clinical Syndromes: Community-Acquired Infections121 PneumoniaLionel A. Mandell, Richard G. Wunderink122 Lung AbscessRebecca M. Baron, Miriam Baron Barshak123 Infective EndocarditisAdolf W. Karchmer124 Infections of the Skin, Muscles, and Soft TissuesDennis L. Stevens125 Infectious ArthritisLawrence C. Madoff126 OsteomyelitisWerner Zimmerli127 Intraabdominal Infections and AbscessesMiriam Baron Barshak, Dennis L. Kasper128 Acute Infectious Diarrheal Diseases and Bacterial Food PoisoningRichelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque129 Clostridium difficile Infection, Including Pseudomembranous ColitisDale N. Gerding, Stuart Johnson130 Urinary Tract Infections, Pyelonephritis, and ProstatitisKalpana Gupta, Barbara W. Trautner131 Sexually Transmitted Infections: Overview and Clinical ApproachJeanne M. Marrazzo, King K. Holmes132 EncephalitisKaren L. Roos, Kenneth L. Tyler133 Acute MeningitisKaren L. Roos, Kenneth L. Tyler134 Chronic and Recurrent MeningitisWalter J. Koroshetz, Michael R. Wilson, Avindra Nath135 Brain Abscess and EmpyemaKaren L. Roos, Kenneth L. Tyler136 Infectious Complications of BitesSandeep S. Jubbal, Florencia Pereyra, Lawrence C. MadoffSection 3: Clinical Syndromes: Health Care-Associated Infections137 Infections Acquired in Health Care FacilitiesRobert A. Weinstein138 Infections in Transplant RecipientsRobert W. Finberg, Joyce D. FingerothSection 4: Therapy for Bacterial Diseases139 Treatment and Prophylaxis of Bacterial InfectionsDavid C. Hooper, Erica S. Shenoy, Christy A. Varughese140 Bacterial Resistance to Antimicrobial AgentsDavid C. HooperSection 5: Diseases Caused by Gram-Positive Bacteria141 Pneumococcal InfectionsDavid Goldblatt, Katherine L. O'Brien142 Staphylococcal InfectionsFranklin D. Lowy143 Streptococcal InfectionsMichael R. Wessels144 Enterococcal InfectionsCesar A. Arias, Barbara E. Murray145 Diphtheria and Other Corynebacterial InfectionsWilliam R. Bishai, John R. Murphy146 Listeria monocytogenes InfectionsElizabeth L. Hohmann, Daniel A. Portnoy147 TetanusC. Louise Thwaites, Lam Minh Yen148 BotulismAgam K. Rao, Susan Maslanka149 Gas Gangrene and Other Clostridial InfectionsAmy E. Bryant, Dennis L. StevensSection 6: Diseases Caused by Gram-Negative Bacteria150 Meningococcal InfectionsAndrew J. Pollard 151 Gonococcal InfectionsSanjay Ram, Peter A. Rice152 Haemophilus and Moraxella InfectionsTimothy F. Murphy153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative BacteriaTamar F. Barlam, Dennis L. Kasper154 Legionella InfectionsVictor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin155 Pertussis and Other Bordetella InfectionsKarina A. Top, Scott A. Halperin156 Diseases Caused by Gram-Negative Enteric BacilliThomas A. Russo, James R. Johnson157 Acinetobacter InfectionsRossana Rosa, L. Silvia Munoz-Price158 Helicobacter pylori InfectionsJohn C. Atherton, Martin J. Blaser159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas SpeciesReuben Ramphal160 SalmonellosisDavid A. Pegues, Samuel I. Miller161 ShigellosisPhilippe J. Sansonetti, Jean Bergounioux162 Infections Due to Campylobacter and Related OrganismsBeth D. Kirkpatrick, Martin J. Blaser163 Cholera and Other VibriosesMatthew K. Waldor, Edward T. Ryan 164 BrucellosisNicholas J. Beeching165 TularemiaJeannine M. Petersen, Paul S. Mead166 Plague and Other Yersinia InfectionsMichael B. Prentice167 Bartonella Infections, Including Cat-Scratch DiseaseMichael Giladi, Moshe Ephros168 DonovanosisNigel O'FarrellSection 7: Miscellaneous Bacterial Infections169 NocardiosisGregory A. Filice170 Actinomycosis Thomas A. Russo171 Whipple's DiseaseThomas A. Russo172 Infections Due to Mixed Anaerobic OrganismsNeeraj K. Surana, Dennis L. KasperSection 8: Mycobacterial Diseases173 TuberculosisMario C. Raviglione174 LeprosyRobert H. Gelber175 Nontuberculous Mycobacterial InfectionsSteven M. Holland176 Antimycobacterial AgentsDivya Reddy, Max R. O'DonnellSection 9: Spirochetal Diseases177 SyphilisSheila A. Lukehart178 Endemic TreponematosesSheila A. Lukehart179 LeptospirosisJiri F. P. Wagenaar, Marga G. A. Goris180 Relapsing FeverAlan G. Barbour181 Lyme BorreliosisAllen C. SteereSection 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae182 Rickettsial DiseasesDavid H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas J. Marrie183 Infections Due to MycoplasmasR. Doug Hardy184 Chlamydial InfectionsCharlotte A. Gaydos, Thomas C. QuinnSection 11: Viral Diseases: General Considerations185 Medical VirologyFred Wang, Elliott Kieff186 Antiviral Chemotherapy, Excluding Antiretroviral DrugsLindsey R. BadenSection 12: Infections Due to DNA Viruses187 Herpes Simplex Virus InfectionsLawrence Corey188 Varicella-Zoster Virus InfectionsRichard J. Whitley189 Epstein-Barr Virus Infections, Including Infectious MononucleosisJeffrey I. Cohen190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8Camille Nelson Kotton, Martin S. Hirsch191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus InfectionsFred Wang192 Parvovirus InfectionsKevin E. Brown193 Human Papillomavirus InfectionsDarron R. Brown, Aaron ErmelSection 13: Infections Due to DNA and RNA Respiratory Viruses194 Common Viral Respiratory Infections James E. Crowe, Jr.195 InfluenzaPeter F. WrightSection 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses196 The Human RetrovirusesDan L. Longo, Anthony S. Fauci197 Human Immunodeficiency Virus Disease: AIDS and Related DisordersAnthony S. Fauci, Gregory K. Folkers, H. Clifford LaneSection 15: Infections Due to RNA Viruses198 Viral GastroenteritisUmesh D. Parashar, Roger I. Glass199 Enterovirus, Parechovirus, and Reovirus InfectionsJeffrey I. Cohen200 Measles (Rubeola)Kaitlin Rainwater-Lovett, William J. Moss201 Rubella (German Measles)Laura A. Zimmerman, Susan E. Reef202 MumpsSteven A. Rubin203 Rabies and Other Rhabdovirus InfectionsAlan C. Jackson204 Arthropod-Borne and Rodent-Borne Virus InfectionsJens H. Kuhn, Remi N. Charrel205 Ebolavirus and Marburgvirus InfectionsJens H. KuhnSection 16: Fungal Infections206 Diagnosis and Treatment of Fungal InfectionsJohn E. Edwards, Jr. 207 HistoplasmosisChadi A. Hage, L. Joseph Wheat208 CoccidioidomycosisNeil M. Ampel209 BlastomycosisS. Travis King, Rathel L. Nolan, III 210 CryptococcosisArturo Casadevall211 CandidiasisJohn E. Edwards, Jr.212 AspergillosisDavid W. Denning213 MucormycosisBrad Spellberg, Ashraf S. Ibrahim214 Superficial Mycoses and Less Common Systemic MycosesCarol A. Kauffman215 Pneumocystis InfectionsAlison Morris, Henry MasurSection 17: Protozoal and Helminthic Infections: General Considerations216 Introduction to Parasitic Infections Sharon L. Reed, Charles E. Davis217 Agents Used to Treat Parasitic InfectionsThomas A. MooreSection 18: Protozoal Infections218 Amebiasis and Infection with Free-Living AmebaeRosa M. Andrade, Sharon L. Reed219 MalariaNicholas J. White, Elizabeth A. Ashley220 BabesiosisEdouard Vannier, Peter J. Krause221 LeishmaniasisShyam Sundar222 Chagas Disease and African TrypanosomiasisFrancois Chappuis, Yves Jackson223 Toxoplasma InfectionsKami Kim224 Protozoal Intestinal Infections and TrichomoniasisPeter F. WellerSection 19: Helminthic Infections225 Introduction to Helminthic InfectionsPeter F. Weller226 Trichinellosis and Other Tissue Nematode InfectionsPeter F. Weller227 Intestinal Nematode InfectionsPeter F. Weller, Thomas B. Nutman228 Filarial and Related InfectionsThomas B. Nutman, Peter F. Weller229 Schistosomiasis and Other Trematode InfectionsBirgitte Jyding Vennervald230 Cestode InfectionsA. Clinton White, Jr., Peter F. WellerPart 6: Disorders of the Cardiovascular SystemSection 1: Introduction to Cardiovascular Disorders231 Approach to the Patient with Possible Cardiovascular DiseaseJoseph Loscalzo232 Basic Biology of the Cardiovascular SystemJoseph Loscalzo, Peter Libby, Calum A. MacRae233 Epidemiology of Cardiovascular DiseaseThomas A. Gaziano, J. Michael GazianoSection 2: Diagnosis of Cardiovascular Disorders234 Physical Examination of the Cardiovascular SystemPatrick T. O'Gara, Joseph Loscalzo235 ElectrocardiographyAry L. Goldberger236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography ImagingMarcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon 237 Diagnostic Cardiac Catheterization and Coronary AngiographyJane A. Leopold, David P. FaxonSection 3: Disorders of Rhythm238 Principles of ElectrophysiologyDavid D. Spragg, Gordon F. Tomaselli239 The Bradyarrhythmias: Disorders of the Sinoatrial NodeDavid D. Spragg, Gordon F. Tomaselli240 The Bradyarrhythmias: Disorders of the Atrioventricular NodeDavid D. Spragg, Gordon F. Tomaselli241 Approach to Supraventricular TachyarrhythmiasGregory F. Michaud, William G. Stevenson242 Physiologic and Non-physiologic Sinus Tachycardia Gregory F. Michaud, William G. Stevenson243 Focal Atrial Tachycardia Gregory F. Michaud, William G. Stevenson244 Paroxysmal Supraventricular TachycardiasGregory F. Michaud, William G. Stevenson245 Common Atrial Flutter, Macroreentrant and Multifocal Atrial TachycardiasGregory F. Michaud, William G. Stevenson246 Atrial FibrillationGregory F. Michaud, William G. Stevenson247 Approach to Ventricular Arrhythmias Roy M. John, William G. Stevenson248 Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm Roy M. John, William G. Stevenson249 Sustained Ventricular Tachycardia William G. Stevenson, Roy M. John250 Polymorphic Ventricular Tachycardia and Ventricular FibrillationWilliam G. Stevenson, Roy M. John251 Electrical Storm and Incessant VTWilliam G. Stevenson, Roy M. JohnSection 4: Disorders of the Heart252 Heart Failure: Pathophysiology and DiagnosisDouglas L. Mann, Murali Chakinala253 Heart Failure: ManagementMandeep R. Mehra 254 Cardiomyopathy and MyocarditisNeal K. Lakdawala, Lynne Warner Stevenson, Joseph Loscalzo255 Cardiac Transplantation and Prolonged Assisted Circulation Mandeep R. Mehra256 Aortic Valve DiseasePatrick T. O'Gara, Joseph Loscalzo257 Aortic Regurgitation Patrick T. O'Gara, Joseph Loscalzo258 Mitral StenosisPatrick T. O'Gara, Joseph Loscalzo259 Mitral RegurgitationPatrick T. O'Gara, Joseph Loscalzo260 Mitral Valve ProlapsePatrick T. O'Gara, Joseph Loscalzo261 Tricuspid Valve DiseasePatrick T. O'Gara, Joseph Loscalzo262 Pulmonic Valve DiseasePatrick T. O'Gara, Joseph Loscalzo263 Multiple and Mixed Valvular Heart DiseasePatrick T. O'Gara, Joseph Loscalzo264 Congenital Heart Disease in the AdultAnne Marie Valente, Michael J. Landzberg265 Pericardial DiseaseEugene Braunwald266 Atrial Myxoma and Other Cardiac TumorsEric H. AwtrySection 5: Coronary and Peripheral Vascular Disease267 Ischemic Heart DiseaseElliott Antman, Joseph Loscalzo268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald269 ST-Segment Elevation Myocardial InfarctionElliott M. Antman, Joseph Loscalzo270 Percutaneous Coronary Interventions and Other Interventional ProceduresDavid P. Faxon, Deepak L. Bhatt271 Hypertensive Vascular DiseaseTheodore A. Kotchen272 Renovascular DiseaseStephen C. Textor273 Deep Venous Thrombosis and Pulmonary ThromboembolismSamuel Z. Goldhaber274 Diseases of the AortaMark A. Creager, Joseph Loscalzo275 Arterial Diseases of the ExtremitiesMark A. Creager, Joseph Loscalzo276 Chronic Venous Disease and Lymphedema Mark A. Creager, Joseph Loscalzo277 Pulmonary HypertensionAaron B. Waxman, Joseph LoscalzoPart 7: Disorders of the Respiratory SystemSection 1: Diagnosis of Respiratory Disorders278 Approach to the Patient with Disease of the Respiratory SystemPatricia A. Kritek, Bruce D. Levy279 Disturbances of Respiratory FunctionEdward T. Naureckas, Julian Solway 280 Diagnostic Procedures in Respiratory DiseaseAnne L. Fuhlbrigge, Augustine M.K. Choi Section 2: Diseases of the Respiratory System281 AsthmaPeter J. Barnes282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with EosinophiliaPraveen Akuthota, Michael E. Wechsler283 Occupational and Environmental Lung DiseaseJohn R. Balmes284 BronchiectasisRebecca M. Baron, Miriam Baron Barshak285 Cystic FibrosisEric J. Sorscher286 Chronic Obstructive Pulmonary DiseaseEdwin K. Silverman, James D. Crapo, Barry Make287 Interstitial Lung DiseaseGary M. Hunninghake, Ivan O. Rosas288 Disorders of the PleuraRichard W. Light289 Disorders of the MediastinumRichard W. Light290 Disorders of Ventilation John F. McConville, Julian Solway, Babak Mokhlesi 291 Sleep ApneaAndrew Wellman, Susan Redline292 Lung TransplantationElbert P. Trulock, IIIPart 8: Critical Care MedicineSection 1: Respiratory Critical Care293 Approach to the Patient with Critical IllnessJohn P. Kress, Jesse B. Hall294 Acute Respiratory Distress SyndromeRebecca M. Baron, Bruce D. Levy295 Mechanical Ventilatory SupportBartolome R. CelliSection 2: Shock and Cardiac Arrest296 Approach to the Patient with ShockAnthony F. Massaro297 Sepsis and Septic ShockChristopher W. Seymour, Derek C. Angus298 Cardiogenic Shock and Pulmonary EdemaDavid H. Ingbar, Holger Thiele299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Christine M. Albert, William G. Stevenson Section 3: Neurologic Critical Care300 ComaS. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser 301 Severe Acute Encephalopathies and Critical Care WeaknessJ. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress302 Subarachnoid HemorrhageJ. Claude Hemphill, III, Wade S. Smith, Daryl R. GressPart 9: Disorders of the Kidney and Urinary Tract303 Cellular and Molecular Biology of the KidneyAlfred L. George, Jr., Eric G. Neilson304 Acute Kidney InjurySushrut S. Waikar, Joseph V. Bonventre305 Chronic Kidney Disease Joanne M. Bargman, Karl L. Skorecki306 Dialysis in the Treatment of Renal FailureKathleen D. Liu, Glenn M. Chertow307 Transplantation in the Treatment of Renal FailureJamil Azzi, Edgar L. Milford, Mohamed H. Sayegh, Anil Chandraker 308 Glomerular DiseasesJulia B. Lewis, Eric G. Neilson309 Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and DevelopmentJing Zhou, Martin R. Pollak310 Tubulointerstitial Diseases of the KidneyLaurence H. Beck, Jr., David J. Salant311 Vascular Injury to the KidneyRonald S. Go, Nelson Leung312 NephrolithiasisGary C. Curhan313 Urinary Tract ObstructionJulian L. SeifterPart 10: Disorders of the Gastrointestinal SystemSection 1: Disorders of the Alimentary Tract314 Approach to the Patient with Gastrointestinal DiseaseWilliam L. Hasler, Chung Owyang315 Gastrointestinal EndoscopyLouis Michel Wong Kee Song, Mark Topazian316 Diseases of the EsophagusPeter J. Kahrilas, Ikuo Hirano317 Peptic Ulcer Disease and Related DisordersJohn Del Valle318 Disorders of AbsorptionHenry J. Binder319 Inflammatory Bowel DiseaseSonia Friedman, Richard S. Blumberg320 Irritable Bowel SyndromeChung Owyang321 Diverticular Disease and Common Anorectal DisordersRizwan Ahmed, Susan L. Gearhart322 Mesenteric Vascular InsufficiencySatinderjit Locham, Mahmoud Malas323 Acute Intestinal ObstructionDanny O. Jacobs324 Acute Appendicitis and PeritonitisDanny O. JacobsSection 2: Nutrition 325 Nutrient Requirements and Dietary AssessmentJohanna Dwyer326 Vitamin and Trace Mineral Deficiency and ExcessPaolo M. Suter, Robert M. Russell327 Malnutrition and Nutritional Assessment Gordon L. Jensen328 Enteral and Parenteral NutritionL. John Hoffer, Bruce R. Bistrian, David F. DriscollSection 3: Liver and Biliary Tract Disease329 Approach to the Patient with Liver DiseaseMarc G. Ghany, Jay H. Hoofnagle 330 Evaluation of Liver FunctionDaniel S. Pratt331 The HyperbilirubinemiasAllan W. Wolkoff332 Acute Viral HepatitisJules L. Dienstag333 Toxic and Drug-Induced HepatitisWilliam M. Lee, Jules L. Dienstag334 Chronic HepatitisJules L. Dienstag335 Alcoholic Liver DiseaseMark E. Mailliard, Michael F. Sorrell336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic SteatohepatitisManal F. Abdelmalek, Anna Mae Diehl337 Cirrhosis and Its ComplicationsBruce R. Bacon338 Liver TransplantationRaymond T. Chung, Jules L. Dienstag339 Diseases of the Gallbladder and Bile DuctsNorton J. Greenberger, Gustav PaumgartnerSection 4: Disorders of the Pancreas340 Approach to the Patient with Pancreatic DiseaseDarwin L. Conwell, Norton J. Greenberger, Peter A. Banks341 Acute and Chronic PancreatitisDarwin L. CoNER(01): WOW
