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Full Description
Describes recent advances in reduction, including the use of boron- and aluminum-based hydride reagents, as well as catalytic hydrogenation methods. Reports applications of reduction procedures with emphasis on selectivity, ranging from chemoselective to enantioselective reductions. Offers chapters on different aspects of reduction and presents a complementary mix of academic and industrial research ranging from theory to practical applications. Includes an overview
chapter with 200 references by Nobel laureate H.C. Brown that surveys the development of hydride reduction in organic chemistry over the past 60 years.
Contents
Sixty Years of Hydride Reductions ; New Developments in Chiral Ruthenium (II) Catalysts for Asymmetric Hydrogenation and Synthetic Applications ; Tartrate-Derived Ligands for the Enantioselective LiAIH[4 Reduction of Ketones: A Comparison of TADDOLates and BINOLates ; Electrophilic Assistance in the Reduction of Six-Membered Cyclic Ketones by Alumino- and Borohydrides ; Recent Advances in Asymmetric Reductions with B-Chlorodiisopinocampheylborane ; The Practical Enantioselective Reduction of Prochiral Ketones ; Diphenyloxazaborolidine for Enantioselective Reduction of Ketones ; Diastereo- and Enantioselective Hydride Reductions of Ketone Phosphinyl Imines to Phosphinyl Amines: Synthesis of Protected Amines and Amino Acids ; Remote Acyclic Diastereocontrol in Hydride Reductions of 1,n-Hydroxy Ketones ; Synthesis, Characterization, and Synthetic Utility of Lithium Aminoborohydrides: A New Class of Powerful, Selective, Air-Stable Reducing Agents ; Sodium Borohydride and Carboxylic Acids: A Novel Reagent Combination ; Use of Sodium Triacetoxyborohydride in Reductive Amination of Ketones and Aldehydes