基本説明
Contents: Overview; Epidemiology of Polycystic Ovary Syndrome; Reproductive Abnormalities; Animal Models of Polycystic Ovary Syndrome; Metabolic Abnormalities and Their Relationship to Polycystic Ovary Syndrome; Genetics and Environmental Influences; and more.
Full Description
Polycystic Ovary Syndrome discusses
the use of animal models in the study of PCOS
the occurrence of ovarian and adrenal abnormalities, cardiovascular risks, abnormal insulin secretion, and endothelial dysfunction in PCOS
modern therapeutic modalities, such as manipulation of diet and lifestyle, metabolic phenotyping, and treatment of hyperandrogenism
the effect of PCOS on long-term health
Exploring the direct and indirect effects of PCOS in each stage of life, from puberty and adolescence to adulthood, Polycystic Ovary Syndrome is an in-depth and illuminating source for obstetricians and gynecologists; medical, reproductive, and pediatric endocrinologists; practitioners in family, internal, and pediatric medicine; epidemiologists; developmental biologists and toxicologists; and scientists and medical students in these disciplines.
Contents
Overview
Historical Perspectives
Joseph W. Goldzieher
Epidemiology of Polycystic Ovary Syndrome
Are Women with Polycystic Ovary Syndrome at Risk for Cardiovascular Disease?
David S. Guzick and Evelyn O. Talbott
Polycystic Ovary Syndrome and Long-Term Disease Risks
Caren G. Solomon
Premature Pubarche, Insulin Resistance, and Adolescent Polycystic Ovary
Silva A. Arslanian and Selma Witchel
Reproductive Abnormalities
Morphological and Physiological Correlates of the Polycystic Ovary
Gregory F. Erickson and Shunichi Shimasaki
Ultrasound Examination of Polycystic and Multifollicular Ovaries
Didier Dewailly, Robert Yann, Christophe Lions, and Yves Ardaens
Adrenal Androgen Excess in Polycystic Ovary Syndrome
Ricardo Azziz
Neuroendocrine Dysfunction in Polycystic Ovary Syndrome
John C. Marshall, Christine A. Eagleson, and Christopher R. McCartney
Animal Models of Polycystic Ovary Syndrome
A Transgenic Mouse Model of Functional Ovarian Hyperstimulation: Implications for Polycystic Ovary Syndrome
Gabe E. Owens and John H. Nilson
Prenatal Androgen Excess Programs for Polycystic Ovary Syndrome in Female Rhesus Monkeys
David H. Abbott, Joel R. Eisner, Ricki J. Colman, Joseph W. Kemnitz, and Daniel A. Dumesic
Metabolic Abnormalities and Their Relationship to Polycystic Ovary Syndrome
Regulation of Metabolism and Reproduction Through the Insulin Receptor Substrat Protein Signaling System
Deborah J. Burks and Morris F. White
Molecular Mechanisms of Insulin Action in Polycystic Ovary Syndrome
Andrea Dunaif
Glucose Intolerance in Polycystic Ovary Syndrome: Role of the Beta Cell
David A. Ehrmann
Oligocentric Systems Associated with Central Obesity and Insulin Resistance: Models for Polycystic Ovary Syndrome
John D. Brunzell
Polycystic Ovary Syndrome and Coronary Vascular Disease: The Evidence?
Robert A. Wild
Vascular Function in Polycystic Ovary Syndrome
Helmut O. Steinberg, Giancarlo Paradisi, Marguerite K. Shepard, and Alain D. Baron
Genetics and Environmental Influences
The Genetics of Polycystic Ovary Syndrome: A Model for the Analysis of Complex Genetic Diseases
Margrit Urbanek, Deborah A. Driscoll, Jerome F. Strauss, III, Richard S. Spielman, Xinqi Wu, Andrea Dunaif, and Richard S. Legro
Role of Genes Encoding Steroidogenic Enzymes in Polycystic Ovary Syndrome
Stephen Franks, Neda Gharani, and Mark McCarthy
The Role of Obesity in Polycystic Ovary Syndrome
Ann E. Taylor
Dyslipidemia in Polycystic Ovary Syndrome: Etiology and Response to Treatment
Richard S. Legro
Environmental Factors in Polycystic Overy Syndrome: Are There Plausible Cause-and-Effect Hypotheses?
Claude L. Hughes, Ruchi Mathur, and David Geller
Intervention/Prevention Strategies
Lifestyle Factors and Polycystic Ovary Syndrome
Robert J. Norman and Michael J. Davies
Treatment of Hyperandrogenism
Rogerio A. Lobo
Ovulation Induction: Predictors of Ovarian Response and Clinical Outcomes
Babek Imani, Marinus J. C. Eijkemans, J. Dik F. Habbema, Bart C. J. M. Fauser, and Egbert R. te Velde
Diagnostic Criteria
Polycystic Ovary Syndrome: Diagnostic Criteria
R. Jeffrey Chang
Index
