Full Description
The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. It begins with a succinct overview of the basic neurosciences followed by an evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, fnctional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychaitric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, "Neurobiology of Mental Illness" represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.
Contents
PART 1: INTRODUCTION TO BASIC NEUROSCIENCE - SECTION EDITOR: ERIC J. NESTLER; 1. Overview of Brain Development; 2. Neurochemical Systems in the Central Nervous System; 3. Using Basic Electrophysiology to Understand the Neurobiology of Mental Illness; 4. Principles of Signal Transduction; 5. Mechanisms of Neural Plasticity; 6. Principles of Molecular Biology; 7. Functional Genomics and Models of Mental Illness; PART 2: METHODS OF CLINICAL NEUROBIOLOGICAL RESEARCH - SECTION EDITOR: ROBERT B. INNIS; 8. Contributions of Epidemiology to the Neurobiology of Mental Illness; 9. Basic Methods for Clinical Molecular Genetics of Psychiatric Illness; 10. Methods of Affective Clinical Psychophysiology; 11. Clinical Neurochemistry; 12. Clinical Neuroendocrinology; 13. Neuroimmunology; 14. Cognitive Neuroscience: Bridging Thinking and Feeling to the Brain, and its Implications for Psychiatry; 15. Neuroimaging Methodologies: Utilizing Radiotracers or Nuclear Magnetic Resonance; 16. Methods of Postmortem Investigation of Human Brain; 17. Drug Discovery and Development Methods for Mental Illness; PART 3: PSYCHOSES - SECTION EDITOR: DANIEL WEINBERGER; 18. Diagnostic Classification of the Psychoses: Historical Context and Implications for Neurobiology; 19. Molecular Genetics of Schizophrenia; 20. Animal Models of the Psychoses; 21. Pharmacologic Models of Psychoses; 22. The Neurobiology of Schizophrenia; 23. Functional Brain Imaging Studies in Schizophrenia; 24. Psychophysiological and Information Processing Approaches to Schizophrenia; 25. Principles of the Pharmacotherapy of Schizophrenia; PART 4: MOOD DISORDERS - SECTION EDITOR: CHARLES B. NEMEROFF; 26. Diagnostic Classification of Mood Disorders: Historical Context and Implications for Neurobiology; 27. Linkage and Association Studies of Bipolar Disorders; 28. Animal Models of Mood Disorders; 29. The Cellular Neurobiology of Bipolar Disorder; 30. The Neurochemistry of Depressive Disorders: Preclinical Studies; 31. The Neurochemistry of Depressive Disorders: Clinical Studies; 32. Neuroimaging Studies of Mood Disorders; 33. Principles of the Pharmacotherapy of Depression; 34. Abnormalities of Brain Structure and Function in Mood Disorders Based Upon Postmortem Investigations; PART 5: ANXIETY DISORDERS - SECTION EDITOR: DENNIS S. CHARNEY; 35. Diagnostic Classification of Anxiety Disorders: DSM-V and Beyond; 36. Molecular Genetics of Anxiety; 37. Animal Models of Anxiety Disorders; 38. Structural and Functional Plasticity in the Hippocampal Formation: Stress, Adaptation and Disease; 39. Functional Neuroanatomy of Anxiety and Fear; 40. The Neurobiology of Anxiety Disorders; 41. The Neurobiology and Treatment of Obsessive-Compulsive Disorder; 42. Neuroimaging Studies of Anxiety Disorders; 43. Principles of Pharmacotherapy for the Anxiety Disorders; PART 6: SUBSTANCE ABUSE DISORDERS - SECTION EDITOR: STEVEN E. HYMAN; 44. Animal Models of Addiction; 45. Cellular and Molecular Mechanisms of Drug Addiction; 46. Genetic Epidemiology of Substance Use Disorders; 47. Effects of Drug Abuse on Brain Development; 48. Neuroimaging in Substance Abuse Research; 49. Principles of the Pharmacotherapy of Substance Abuse Disorders; PART 7: DEMENTIA - SECTION EDITOR: KENNETH L. DAVIS; 50. Diagnostic Classifications: Relationship to the Neurobiology of Dementia; 51. The Molecular Biology of Alzheimer's Disease; 52. Pharmacological and Transgenic Animal Models of Alzheimer's Disease; 53. Functional Neuroanatomy of Learning and Memory; 54. Neurochemical Systems Involved in Learning and Memory; 55. Neuropathological and Neuroimaging Studies of the Hippocampus in Normal Aging and in Alzheimer's Disease; 56. Abnormalities in Brain Structure on Postmortem Analysis of Dementia; 57. Functional Brain Imaging Studies in Dementia; 58. Principles of the Pharmacotherapy of Dementia; 59. Cognitive Impairment in Demyelinating Disease; 60. Dementia with Lewy Bodies; 61. Dementia in Parkinson's Disease; PART 8: PSYCHIATRIC DISORDERS OF CHILDHOOD ONSET - SECTION EDITOR: JAMES F. LECKMAN; 62. Developmental Neurobiology and the Childhood Onset of Psychiatric Disorders; 63. Molecular Genetics of Childhood- and Adolescent- Onset Psychiatric Disorders; 64. Neurobiology of Mental Retardation; 65. The Neurobiology of Autism and the Pervasive Developmental Disorders; 66. Tourette's Syndrome and Tic-Related Disorders in Children; 67. Neurobiology of Attention Deficit Hyperactivity Disorder; 68. The Neurobiology of Childhood Psychotic Disorders; 69. Neurobiology of Early-Onset Mood Disorders; 70. Childhood Anxiety Disorders: A Cognitive Neurobiological Perspective; PART 9: SPECIAL TOPIC AREAS - SECTION EDITOR: DENNIS S. CHARNEY; 71. Neuropsychiatry: The Border Between Neurology and Psychiatry; 72. The Neurobiology of Personality and Personality Disorders; 73. The Neurobiology of Aggression; 74. Sexual Dysfunction and Pharmacological Treatments: Biologic Interactions; 75. The Neurobiology of Social Attachment; 76. The Neurobiology of Eating Disorders; 77. The Neurobiology of Menstrual Cycle-Related Mood Disorders; 78. The Neurobiology of Circadian Rhythms; 79. The Neurobiology of Sleep in Relation to Mental Illness; 80. Depression, Cardiovascular Disease, and Cerebrovascular Disease: Implications for Pathophysiology and Treatment
