基本説明
Contains 14 new chapters on topics such as platelet structure, ADP receptors, clinical tests of platelet function, and wound healing.
Full Description
Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.
Contents
Foreword A Brief History of Ideas About Platelets in Health and DiseasePart One: Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. The regulation of platelet life span 4. Platelet Genomics 5. Platelet MicroRNAs 6. The Platelet Proteome 7. Platelet Structure 8. The Platelet Cytoskeleton 9. Platelet Receptors 10. The GPIb-IX-V Complex 11. GPVI and CLEC-2 12. Integrin AlphaIIb Beta3 13. Protease-activated Receptors 14. The Platelet P2 Receptors 15. PECAM-1 16. Interactions Between Platelets, Leukocytes and the Endothelium 17. Inhibition of Platelet Function by the Endothelium 18. Platelet Secretion 19. Signal Transduction During Platelet Plug Formation 20. Platelet Thrombus Formation in Flowing Blood 21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Microparticles 23. The Role of Platelets in Fibrinolysis 24. The Role of Platelets in Angiogenesis 25. Platelet Function in the NewbornPart Two: Tests of Platelet Function 26. Clinical Tests of Platelet Function 27. Platelet Counting 28. Platelet Aggregation 29. Flow Cytometry 30. Monitoring of Antiplatelet Therapy 31. Real Time In Vivo Imaging of Platelets During Thrombus FormationPart Three: The Role of Platelets in Disease 32. Atherothrombosis and Coronary Artery Disease 33. Central Nervous System Ischemia 34. Peripheral Vascular Disease 35. Diabetes Mellitus 36. Inflammation 37. Antimicrobial Host Defense 38. Tumor Growth and MetastasisPart Four: Disorders of Platelet Number and Function 39. The Clinical Approach to Disorders of Platelet Number and Function 40. Immune Thrombocytopenia (ITP) 41. Drug-induced Thrombocytopenia 42. Heparin-induced Thrombocytopenia 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome 44. Thrombocytopenia in Pregnancy 45. Thrombocytopenia in the Newborn 46. Alloimmune Thrombocytopenia 47. Inherited Thrombocytopenias 48. Pseudothrombocytopenia 49. Thrombocytosis and Essential Thrombocythemia 50. Congenital Disorders of Platelet Function 51. Acquired Disorders of Platelet Function 52. Cardiopulmonary BypassPart Five: Antiplatelet Therapy 53. Aspirin 54. ADP Receptor Antagonists 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists 56. Dipyridamole 57. Cilostazol 58. Novel Antiplatelet Therapies Part Six: Therapy to Increase Platelet Numbers and/or Function 59. Thrombopoietin Mimetics 60. Desmopressin 61. Factor VIIa 62. Platelet Transfusion Medicine 63. Making Platelets Ex Vivo 64. Gene Therapy for Platelet Disorders
