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基本説明
Presents step-by-step techniques for researchers that will predict the structured and potential function of proteins by identifying its coding sequence.
Full Description
Structural genomics is the systematic determination of 3D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
Contents
Graphical representation and mathematical characterization of protein sequences and applications to viral proteinsAmbarnil Ghosh and Ashesh Nandy
Structural, thermodynamic and mechanistical studies in uroporphyrinogen III synthase. Molecular basis of congenital erythropoietic porphyriaArola Fortian, David Castaño, Esperanza Gonzalez, Ana Laín, Juan M. Falcon-Perez and Oscar Millet
Role of Fibrin Structure in Thrombosis and Vascular DiseaseAmy L. Cilia La Corte, Helen Philippou and Robert A. S. Ariëns
Structural, Dynamic, and Functional Aspects of Helix Association in Membranes: a Computational ViewAnton A. Polyansky, Pavel E. Volynsky, Roman G. Efremov
Proteins MOVE! Protein dynamics and long-range allostery in cell signalingZimei Bu and David J. E. Callaway
Structural diversity of class I MHC like molecules and its implications in binding specificitiesMd. Imtaiyaz Hassan and Faizan Ahmad
