Full Description
This volume provides an overview of exacerbation models of asthma and chronic obstructive pulmonary disease (COPD). Within this wide field the book focuses on experimental systems that mimic pathobiological processes likely to be critical in exacerbations of these conditions. To generate insight into the mechanisms of exacerbation of pulmonary disease and to promote the discovery of future treatments, both animal models and human experimental models are described. For this update some of the most eminent scientists within the area of pulmonology could be recruited to share their knowledge of this evolving field of human medicine. Models of Exacerbations in Asthma and COPD will be of great interest to pulmonologists, allergologists, specialists in internal medicine and critical care, as well as to microbiologists, infectiologists and pharmacologists studying the response to respiratory infections.
Contents
Foreword: Sjobring, U.; Taylor, J.D.; Introduction; Exacerbations of Asthma and COPD: Definitions, Clinical Manifestations and Epidemiology: O'Byrne, P.M.; Human Asthma Models; Human Rhinovirus Models in Asthma: Singh, A.M.; Busse, W.W.; Allergen Inhalation Challenge: A Human Model of Asthma Exacerbation: Gauvreau, G.M.; Evans, M.Y.; Animal Asthma Models; Cellular and Animals Models for Rhinovirus Infection in Asthma: Xatzipsalti, M.; Papadopoulos, N.G.; Modeling Responses to Respiratory House Dust Mite Exposure: Cates, E.C.; Fattouh, R.; Johnson, J.R.; Llop-Guevara, A.; Jordana, M.; Respiratory Syncytial Virus-Induced Pulmonary Disease and Exacerbation of Allergic Asthma: Lukacs, N.W.; Smit, J.; Lindell, D.; Schaller, M.; Human COPD Models; Lipopolysaccharide Challenge of Humans as a Model for Chronic Obstructive Lung Disease Exacerbations: Kharitonov, S.A.; Sjobring, U.; A Human Rhinovirus Model of Chronic Obstructive Pulmonary Disease Exacerbations: Contoli, M.; Caramori, G.; Mallia, P.; Papi, A.; Johnston, S.L.; Animal COPD Models; Animal Models of Cigarette Smoke-Induced Chronic Obstructive Lung Disease: Churg, A.; Wright, J.L.; Animal Models of Chronic Obstructive Pulmonary Disease Exacerbations: Gaschler, G.J.; Bauer, C.M.T.; Zavitz, C.C.J.; Stampfli, M.R.; Author and Subject Index.
