ＤＮＡ修復と突然変異（第２版） DNA Repair and Mutagenesis （2ND）

Friedberg, Errol C. (EDT)/ Walker, Graham C./ Siede, Wolfram/ Schultz,

Amer Soc for Microbiology（2005/11発売）

• 製本 Hardcover:ハードカバー版／ページ数 1118 p.
• 言語 ENG
• 商品コード 9781555813192
• DDC分類 572.86459

基本説明

Featuring more than 10,000 references, it is a timely update to the original edition published in 1995. Features a 12-page full-color insert and over 700 illustrations, including protein structures. Divided into five main parts: sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

Full Description

An essential resource for all scientists researching cellular responses to DNA damage. * Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. * Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. * Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Contents

Table of ContentsPart 1. Sources and Consequences of DNA Damage1. Introduction: Biological Responses to DNA Damage 2. DNA Damage 3. Introduction to MutagenesisPart 2. Correcting Altered Bases in DNA: DNA Repair4. Reversal of Base Damage Caused by UV Radiation 5. Reversal of Alkylation Damage in DNA 6. Base Excision Repair 7. Nucleotide Excision Repair: General Features and the Process in Prokaryotes 8. Nucleotide Excision Repair in Eukaryotes: Cell Biology and Genetics 9. Mechanism of Nucleotide Excision Repair in Eukaryotes 10. Heterogeneity of Nucleotide Excision Repair in Eukaryotic Genomes 11. Alternative Excision Repair of DNA 12. Mismatch Repair 13. Repair of Mitochondrial DNA DamagePart 3. DNA Damage Tolerance and Mutagenesis14. The SOS Responses of Prokaryotes to DNA Damage 15. Mutagenesis and Translesion Synthesis in Prokaryotes 16. Recombinational Repair, Replication Fork Repair, and DNA Damage Tolerance 17. DNA Damage Tolerance and Mutagenesis in Eukaryotic Cells 18. Managing DNA Strand Breaks in Eukaryotic Cells: Repair Pathway Overview and Homologous Recombination 19. Managing DNA Strand Breaks in Eukaryotic Cells: Nonhomologous End Joining and Other PathwaysPart 4. Regulatory Responses to DNA Damage in Eukaryotes20. Cell Cycle Checkpoints: General Introduction and Mechanisms of DNA Damage Sensing 21. Cell Cycle Checkpoints: Signal Transmission and Effector Targets 22. Transcriptional Responses to DNA Damage 23. DNA Damage and the Regulation of Cell FatePart 5. Disease States Associated with Defective Biological Responses to DNA Damage24. Xeroderma Pigmentosum: a Disease Associated with Defective Nucleotide Excision Repair or Defective Translesion DNA Synthesis 25. Other Diseases Associated with Defects in Nucleotide Excision Repair of DNA 26. Diseases Associated with Defective Responses to DNA Strand Breaks 27. Diseases Associated with Disordered DNA Helicase Function 28. Additional Diseases Associated with Defective Responses to DNA Damage 29. Hereditary Diseases that Implicate Defective Responses to DNA Damage 30. DNA Polymorphisms in Gatekeeper and Guardian GenesAppendixTable 1. Nomenclature of DNA repair genes Table 2. Human hereditary diseases and defective cellular responses to DNA damage