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Full Description
The purpose of this book is to account for the structure and function of genes in terms of extensive knowledge about both prokaryotes and eukaryotes. It explains what a gene is, how it is reproduced and what controls its expression. This new edition has completely new chapters on protein trafficking and eukaryotic gene transcription. It has a new introduction to the subject, making the book more approachable to less advanced students. Chapters on bacterial transcriptions, post-transcriptional control, interrupted gene structure, RNA splicing, transposons in bacteria, transposable elements in eukaryotes, gene expression in development, and the role of oncogenes in carcinogenesis have been completely rewritten.
Contents
Introduction: Cells as macromolecular assemblies: cells obey the laws of physics and chemistry; cells are organized into compartments. Part 1 DNA as a store of information: genes are mutable units; DNA is the genetic material; the topology of nucleic acids; isolating the gene. Part 2 Translation - expressing genes as proteins: the assembly line for protein synthesis; transfer RNA - the translational adaptor; the ribosome translation factory; the messenger RNA template; the apparatus for protein localization. Part 3 Transcription - control of prokaryotic genes: control at initiation - RNA polymerase-promoter interactions; a panoply of operons - the lactose paradigm and others; posttranscriptional feedback and control; control at termination - attenuation and antitermination; lytic cascades and lysogenic repression. Part 4 Perpetuation of DNA: the replicon - unit of replication; the apparatus for DNA replication; systems that safeguard DNA. Part 5 The packaging of DNA: about genomes and chromosomes; organization of nucleosomes in chromatin; the nature of active chromatin. Part 6 Constitution of the eukaryotic genome: the extraordinary power of DNA technology; a continuum of sequences includes structural genes; the organization of interrupted genes; structural genes evolve in families; genomes sequestered in organelles; organization of simple sequence DNA. Part 7 Reaching maturity - eukaryotic RNA synthesis and processing: building the transcription complex; mechanisms of RNA splicing; control of RNA processing. Part 8 The dynamic genome - DNA in flux: recombination and other topological manipulations; transposons that mobilize via DNA; retroviruses and retroposons; engineering changes in the genome. Part 9 Genes in development: generation of immune diversity involves reorganization of the genome; changing gene organization from within and without; gene regulation in development - cascades and gradients; oncogenes - aberrant gene expression and cancer. Epilogue: landmark shifts in perspectives.
